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抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7407	Thyrotropin-Releasing Hormone (TRH), Free Acid TRH-OH	Others	Others
	Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) 是一种促甲状腺激素释放激素的生理代谢产物。
TP1022	Protirelin Acetate TSH-RF Acetate,TRH Acetate,TRF Acetate,醋酸普罗瑞林	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Protirelin Acetate (TRH Acetate) 是高度保守的神经肽，具有促甲状腺激素水平的激素控制作用，及神经调节的能力。
T34923	TRH tartrate
	TRH tartrate is a thyrotropin-releasing hormone.
TP2201	TRH Precursor Peptide	Others	Others
	Thyrotropin Releasing Hormone Precursor Peptide
T6956L	Protirelin Acetate(24305-27-9 free base) Thyroliberin Acetate,TRF Acetate,Synthetic thyrotropin-releasing hormone Acetate,Lopremone Acetate,pGlu-His-Pro-NH2 Acetate,TRH Acetate	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Protirelin Acetate(24305-27-9 free base) (Thyroliberin Acetate) 是一种三肽，可刺激促甲状腺素和催乳素的释放。
T77258	Trh-gly
	Trh-gly (TRH-glycine) 是促甲状腺素 (TSH) 释放激素 (TRH) 的前体，可释放促甲状腺素和催乳素。
T76494	[Phe2]-TRH
	[Phe2]-TRH 是一种促甲状腺激素释放激素类似物，与 Leu5-脑啡肽具有构象相似性。
T76493	(Glu2)-TRH
	(Glu2)-TRH 是一种代谢稳定的 Thyrotropin-releasing hormone(TRH) 类似物，是小鼠大脑中 TRH 胆碱能作用的负调节剂。(Glu2)-TRH 显着减弱 TRH 诱导的海马细胞外乙酰胆碱释放。(Glu2)-TRH 不被甲状腺解放酶代谢。(Glu2)-TRH 在中枢神经系统中表现出神经保护、抗抑郁、抗惊厥作用。
T34869	Thyrotropin-releasing hormone, deamido- Deamido-trh,Pyroglutamyl-histidyl-proline,Trh-OH,Trh, deamido-,Pglu-his-pro
	Thyrotropin-releasing hormone, deamido- is a biochemical.
T34206	Pyroglutaminyl-seryl-leucinamide Thyrotropin releasing hormone-AN,Trh-AN,Pyr-ser-leu-NH2
	Pyroglutaminyl-seryl-leucinamide is a bioactive chemical.
T76496	Prepro-TRH-(160-169)
	Prepro-TRH-(160-169)，作为促甲状腺激素释放激素原 (pro-TRH) 的连接肽之一，具有增强TRH诱导的促甲状腺激素 (TSH) 释放的功能。
T13072	Taltirelin acetate TA-0910 acetate	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Taltirelin acetate (TA-0910 acetate) 是促甲状腺激素释放激素受体(TRH-R)超激动剂(IC50:910 nM)，能够刺激细胞溶质Ca2+浓度增加 (Ca2+释放) ，其EC50值为 36 nM。
T34399	Rovatirelin KPS-0373,S0373,S-0373,S 0373	AChE	Neuroscience
	Rovatirelin (S-0373) 是一种新合成的促甲状腺激素释放激素（TRH）类似物，通过乙酰胆碱和多巴胺神经传递改善胞嘧啶阿拉伯糖苷诱导的脊髓小脑变性大鼠模型的运动功能障碍。
T30269	Azetirelin Azetirelinum,Azetirelina
	Azetirelin, as a TRH analog, has a more potent effect than TRH on the central nervous system.
T32083	Histidylprolineamide His-pro-amide
	Histidylprolineamide is the N-terminal of TRH.
T33438	MK771 MK-771,MK 771
	MK771 is a therapeutic agent and an analog of the Thyrotropin Releasing Hormone (TRH). TRH and its analogs may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects.
T19511	PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	Others	Others
	PGlu-3-methyl-His-Pro-NH2 TFA, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.
TP2011	JKC363 JKC 363
	Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 0.5 and 44.9 nM at MC4 and MC3 respectively) that antagonizes the effects of α-MSH. Suppresses thyrotropin-releasing hormone (TRH) release, attenuates food intake and reduces forma
T7590	Taltirelin TA-0910,他替瑞林	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Taltirelin (TA-0910) 是促甲状腺激素释放激素受体(TRH-R)超激动剂(IC50:910 nM)，能够刺激细胞溶质 Ca2+浓度增加 (Ca2+释放) (EC50:36 nM)。
T75850	JKC363 TFA
	JKC363 TFA为选择性MC4受体拮抗剂，MC4受体(IC50=0.5 nM)亲和力是MC3受体(44.9 nM)的90倍。JKC363 TFA能阻断α-MSH对TRH释放的刺激，显示出抗痛觉效果。

化合物

Thyrotropin-Releasing Hormone (TRH), Free Acid

Cat.No: T7407

Synonym: TRH-OH

Target: Others

Protirelin Acetate

Cat.No: TP1022

Synonym: TSH-RF Acetate,TRH Acetate,TRF Acetate,醋酸普罗瑞林

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Cat.No: T34923

TRH Precursor Peptide

Cat.No: TP2201

Target: Others

Protirelin Acetate(24305-27-9 free base)

Cat.No: T6956L

Synonym: Thyroliberin Acetate,TRF Acetate,Synthetic thyrotropin-releasing hormone Acetate,Lopremone Acetate,pGlu-His-Pro-NH2 Acetate,TRH Acetate

Target: Thyroid hormone receptor(THR)

Cat.No: T77258

Cat.No: T76494

Cat.No: T76493

Thyrotropin-releasing hormone, deamido-

Cat.No: T34869

Synonym: Deamido-trh,Pyroglutamyl-histidyl-proline,Trh-OH,Trh, deamido-,Pglu-his-pro

Pyroglutaminyl-seryl-leucinamide

Cat.No: T34206

Synonym: Thyrotropin releasing hormone-AN,Trh-AN,Pyr-ser-leu-NH2

Prepro-TRH-(160-169)

Cat.No: T76496

Taltirelin acetate

Cat.No: T13072

Synonym: TA-0910 acetate

Target: Thyroid hormone receptor(THR)

Cat.No: T34399

Synonym: KPS-0373,S0373,S-0373,S 0373

Target: AChE

Cat.No: T30269

Synonym: Azetirelinum,Azetirelina

Histidylprolineamide

Cat.No: T32083

Synonym: His-pro-amide

Cat.No: T33438

Synonym: MK-771,MK 771

PGlu-3-methyl-His-Pro-NH2 TFA

Cat.No: T19511

Synonym: A-42872 TFA

Target: Others

Cat.No: TP2011

Synonym: JKC 363

Cat.No: T7590

Synonym: TA-0910,他替瑞林

Target: Thyroid hormone receptor(THR)

Cat.No: T75850

Cat. No.	Product Name	Target	Signaling Pathways
T6956	Protirelin Lopremone,pGlu-His-Pro-NH2,Synthetic thyrotropin-releasing hormone,Thyroliberin,TRH,普罗瑞林,TRF	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Protirelin (Thyroliberin) 是高度保守的神经肽，具有促甲状腺激素水平的激素控制作用，及神经调节功能。

天然产物

Cat.No: T6956

Synonym: Lopremone,pGlu-His-Pro-NH2,Synthetic thyrotropin-releasing hormone,Thyroliberin,TRH,普罗瑞林,TRF

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

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