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Cat. No. Product Name Target Signaling Pathways
TNU1309 TLR7 agonist 10

TLR7 agonist 10 is a Nucleoside Derivative - Xylo-nucleoside, N-Methylated alkylated nucleoside; 8-Modified purine nucleoside.
T8316 1V209

TLR7 agonist T7

TLR Immunology/Inflammation
1V209 (TLR7 agonist T7) 是一种 Toll 样受体 7 (TLR7) 激动剂,可与各种多糖缀合,以改善其水溶性,增强功效并保持低毒性,具有抗肿瘤作用。
T39968 TLR7/8 agonist 4 hydroxy-PEG10-acid

TLR7/8 agonist 4 hydroxy-PEG10-acid

TLR7/8 agonist 4 hydroxy-PEG10-acid (compound 9) is a drug-linker conjugate employed in antibody-drug conjugates (ADC). This compound exhibits remarkable antitumor activity by utilizing TLR7/8 agonist 4, which acts as a potent activator of TLR7/8. The TLR7/8 agonist 4 is linked to hydroxy-PEG10-acid, the ADC linker, via a cleavable bond. Overall, it demonstrates promising pharmaceutical potential in the context of ADC-based therapeutics.
T39970 TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) is a drug-linker conjugate used in antibody-drug conjugates (ADCs) with high efficacy against tumors. It consists of TLR7/8 agonist 4, a potent TLR7/8 agonist, linked to the ADC linker hydroxy-PEG10-acid which can be cleaved.
T15371 Gardiquimod

TLR; HIV Protease Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
Gardiquimod 可抑制巨噬细胞和活化的外周血单个核细胞的HIV-1感染。 它是一种咪唑喹啉类似物,是一种 TLR7/8 激动剂。
T5499 gardiquimod TFA salt

Gardiquimod diTFA,咪唑啉类似物TLR7/8激动剂,可特异性抑制巨噬细胞和活化外周血单个核细胞(PBMCs)的HIV-1感染。在浓度低于10 μM时,该化合物特异性激活TLR7
T61390 D18

D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively). It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].

化合物

TLR7 agonist 10
Cat.No: TNU1309
Synonym:
Target:
1V209
Cat.No: T8316
Synonym: TLR7 agonist T7
Target: TLR
TLR7/8 agonist 4 hydroxy-PEG10-acid
Cat.No: T39968
Synonym: TLR7/8 agonist 4 hydroxy-PEG10-acid
Target:
TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride
Cat.No: T39970
Synonym: TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride
Target:
Gardiquimod
Cat.No: T15371
Synonym:
Target: TLR, HIV Protease
gardiquimod TFA salt
Cat.No: T5499
Synonym:
Target:
D18
Cat.No: T61390
Synonym:
Target:
TargetMol Loading
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