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Cat. No.	Product Name	Target	Signaling Pathways
T72064	TASK-1-IN-1	Potassium Channel	Membrane transporter/Ion channel
	TASK-1-IN-1 是一种有效的选择性的 TASK-1 (Potassium Channel) 抑制剂（IC50 ： 148 nM）。TASK-1-IN-1 对 TASK-3 通道的IC50 为 1750 nM，抑制作用有所降低。TASK-1-IN-1 具有抗癌作用。
T4316	ML365	Potassium Channel	Membrane transporter/Ion channel
	ML365 是有效的，选择性的双孔结构域钾通道TASK1/KCNK3抑制剂，IC50为 4 nM。它可用于检查 TASK1 通道的特定作用。
T7774	A2793 2-[(5-氯-8-喹啉基)氧基]乙酸乙酯	Potassium Channel	Membrane transporter/Ion channel
	A2793 是 TWIK 相关酸敏感 K+通道 1(TASK-1)/TRESK 的双重抑制剂，对 mTRESK 的 IC50为 6.8 μM。它对 TRESK 选择性更好, 对 TREK-1 和 TALK-1 相对弱一些。
T0038	Doxapram hydrochloride hydrate 多沙普仑盐酸一水合物,盐酸多沙普仑,Doxapram hydrochloride monohydrate,Doxapram HCl	Potassium Channel	Membrane transporter/Ion channel
	Doxapram hydrochloride hydrate (Doxapram HCl) 是 TASK-1，TASK-3和 TASK-1/TASK-3异二聚体通道的抑制剂，EC50分别为410 nM，37 μM 和9 μM。
T68730	AVE1231	Potassium Channel	Membrane transporter/Ion channel
	AVE1231 是一种 TASK-1 通道阻滞剂，抑制 TASK-1 ，可用于研究心房颤动。
T72066	CHET3	Potassium Channel	Membrane transporter/Ion channel
	CHET3 is a TASK-3 inhibitor that can be used to study pain.
T37190	L-Allylglycine	Dehydrogenase; GABA Receptor	Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Allylglycine 是 GABA 合成酶（谷氨酸脱羧酶）的有效抑制剂。
T24993	A1899 S20951,S 20951,A-1899,S-20951,A 1899
	A1899 is a effective and selective TASK-1 and TASK-3 antagonist.
T22315	Doxapram	Others	Others
	Doxapram, a central respiratory stimulant with a brief duration of action, is a selective TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel inhibitor with EC50 of 410 nM, 37 μM, 9 μM, respectively.
T24648	PK-THPP
	PK-THPP is a channel blocker of TASK-3.
T22734	DL-AP7	Others	Others
	DL-AP7 是一种竞争性NMDA 拮抗剂和抗惊厥剂。DL-AP7 阻断 NMDA 诱导的惊厥,并导致小鼠在被动回避任务中的学习表现受损。
T70224	Bupivacaine tartrate
	Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intracellular portion of voltage-gated sodium channels and blocking sodium influx into nerve cells.
T75137	BAY-747
	BAY-747 (BAY 1165747) 为一种通过口服生效且具有脑渗透性的sGC刺激剂。它能可逆地逆转L-NAME所诱导的记忆障碍并在大鼠中增强认知功能。BAY-747还可在有意识状态下降低正常血压及自发性高血压大鼠(SHR)的血压。此外，BAY-747在mdx/mTRG2小鼠模型中改善了与Duchenne肌营养不良症(DMD)相关的骨骼肌功能。
T37791	A-971432
	A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 &#181M, respectively). It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 &#181M) increases electrical resistance of hCMEC/D3 cells in an in vitro blood-brain barrier model, indicating enhanced barrier integrity, and attenuates blood-brain barrier leakage in an R6/2 transgenic mouse model of Huntington’s ...
T37800	PF-04449613
	PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-0444...
T36947	Pyrithiamine (hydrobromide)
	Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growth media and induces symptoms of thiamine deficiency in mice at a dietary ratio of 3:1. These effects are reversible with addition of sufficient thiamine in all species. Pyrithiamine inhibits the formation of cocarboxylase from thiamine in chicken blood in a dose-dependent manner....

化合物

Cat.No: T72064

Target: Potassium Channel

Cat.No: T4316

Target: Potassium Channel

Cat.No: T7774

Synonym: 2-[(5-氯-8-喹啉基)氧基]乙酸乙酯

Target: Potassium Channel

Doxapram hydrochloride hydrate

Cat.No: T0038

Synonym: 多沙普仑盐酸一水合物,盐酸多沙普仑,Doxapram hydrochloride monohydrate,Doxapram HCl

Target: Potassium Channel

Cat.No: T68730

Target: Potassium Channel

Cat.No: T72066

Target: Potassium Channel

Cat.No: T37190

Target: Dehydrogenase, GABA Receptor

Cat.No: T24993

Synonym: S20951,S 20951,A-1899,S-20951,A 1899

Cat.No: T22315

Target: Others

Cat.No: T24648

Cat.No: T22734

Target: Others

Bupivacaine tartrate

Cat.No: T70224

Cat.No: T75137

Cat.No: T37791

Cat.No: T37800

Pyrithiamine (hydrobromide)

Cat.No: T36947

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