Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14378L |
AZD5582 acetate (1258392-53-8 free base)
|
IAP | Apoptosis |
AZD5582 acetate (1258392-53-8 free base) 是一种 IAP 抑制剂,与 BIR3 结构域 cIAP1、cIAP2 和 XIAP 结合,IC50 分别为 15、21 和 15 nM。 AZD5582 诱导细胞凋亡。 | |||
T14378 |
AZD5582
|
Apoptosis; IAP | Apoptosis |
AZD5582 是一种 IAP 拮抗剂,可诱导凋亡,可与 cIAP1、cIAP2 和 XIAP 的 BIR3 结构域结合,IC50值分别为 15、21和15 nM。 | |||
T36201L |
AZD5582 TFA
AZD5582 TFA(1258392-53-8 free base) |
Apoptosis; IAP | Apoptosis |
AZD5582 TFA 是一种有效的 IAP 拮抗剂,可与 cIAP1,cIAP2 和 XIAP 的 BIR3 结构域结合, IC50 值分别为 15,21,15 nM。AZD5582 TFA可诱导细胞凋亡。 | |||
T36201 |
AZD5582 dihydrochloride
AZD 5582 dihydrochloride |
||
Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice. Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP... |