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26

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37681	3-hydroxy Stearic Acid 3-hydroxystearic acid,3-hydroxyoctadecanoic acid
	3-hydroxy Stearic Acid (3-hydroxystearic acid) 是从假单胞菌和菌丝桃属植物中发现的一种脂肪酸。
T35684	2-Hydroxystearic acid 2-Hydroxy stearic acid,DL-2-Hydroxystearic acid
	2-Hydroxystearic acid 是一种从人类和 U. armoricana 中发现的羟基脂肪酸。当使用浓度为 100 μM 时，它能减少艾氏腹水瘤（EAT）细胞在体外的生长。
T37278	2-chloro Stearic Acid
	2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate . It induces DNA release from primary human neutrophils. 2-chloro Stearic acid is toxic to C. quinquefasciatus larvae (LC50 = <1 ppm).
T36456	12-hydroxy Stearic Acid
	12-hydroxy Stearic acid is a hydroxy fatty acid produced by the hydrogenation of ricinoleic acid .1It is a low molecular weight gelator that self-assembles to form organogels.2Administration of paclitaxel in 12-hydroxy stearic acid-containing gel nanocarriers enhances tumor growth suppression in an H22 murine hepatocellular carcinoma model.3Formulations containing 12-hydroxy stearic acid have been used in cosmetic products as emollients. 1.Fameau, A.-L., and Rogers, M.A.The curious case of 12-hy...
T41254	Stearic acid-1-13C

T33343	Methyl stearic acid
	Methyl stearic acid is a bioactive chemical.
T35703	2-hydroxy Stearic Acid methyl ester
	2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides.
T14186	17-ODYA 17-十八炔酸,Alkynyl Stearic Acid	Others; PROTAC Linker	Others; PROTAC
	17-ODYA (Alkynyl Stearic Acid) 是 CYP450 ω-羟化酶抑制剂。它能够抑制与花生四烯酸孵育的大鼠肾皮质微粒体形成 20-HETE 、dihydroxyeicosatrienoic acids、epoxyeicosatrienoic acids。它可以改善异丙肾上腺素诱导的培养心肌细胞凋亡和坏死。
T65291	12-oxo Stearic Acid methyl ester
	12-oxo Stearic Acid methyl ester 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65291，CAS号为 2380-27-0。
T20767	Sorbitan monostearate Span 55,Emsorb 2505,Sorbon S 60,Liposorb S-20,Sorgen 50
	Sorbitan monostearate is an ester of stearic acid and sorbitan (a sorbitol derivative), it is also sometimes referred to as a synthetic wax.
T36590	9-PAHSA
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxylated C-16 or C-18 lipid. 9-PAHSA is a FAHFA in which palmitic acid is esterified to 9-hydroxy stearic acid. PAHSAs are the most abundant forms of FAHFA in serum as well as whi...
T37485	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by 15-lipoxygenase (15-LO).
T40663	9,10-Dichlorostearic acid
	9,10-Dichlorostearic acid is a chlorinated stearic acid that possesses antimutagenic properties. In vitro studies show that this compound induces membrane damage in mammalian tumor cells by causing leakage of adenosine triphosphate (ATP).
T36142	10-PAHSA
	10-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue. As other FAHFAs improve glucose tolerance, stimulate insulin secretion, and have anti-...
T36768	1-Octadecyl Lysophosphatidic Acid
	1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA recepto...
T38217	1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE
	1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid and adrenic acid at thesn-1 andsn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus.1 1.Hancock, S.E., Friedrich, M.G., Mitchell, T.W., et al.Decreases in phospholipids containing adrenic and arachidonic acids occur in the human hippocampus over the adult lifespanLipids50(9)861-872(2015)
T38358	1,3-Distearoyl-2-Oleoyl-rac-glycerol
	1,3-Distearoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains stearic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position. It has been found in Kpangnana, Chinese tallow, and cocoa butters. 1,3-Distearoyl-2-oleoyl-rac-glycerol increases the phagocytic function of reticulo-endothelial cells in mice when administered at doses of 5 and 10 mg per animal.
T35443	1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol
	1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic , stearic , and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been detected in RAW 264.7 cells by neutral loss MS. Increased serum levels of 1-palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol are a potential biomarker for non-alcoholic fatty liver disease (NAFLD).
T36586	12-PAHSA
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-PAHSA is a FAHFA in which palmitic acid is esterified at the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, PAHSAs ar...
T37486	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is toxic to human umbilical vein endothelial cells (HUVECs) when used at a concentration of 100 μM.
T37487	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
T35445	1-Stearoyl-3-Oleoyl-rac-glycerol
	1-Stearoyl-3-oleoyl-rac-glycerol is a diacylglycerol that contains stearic acid at the sn-1 position and oleic acid at the sn-3 position. Intermittent fasting decreases skeletal muscle and hepatic levels of 1-stearoyl-3-oleoyl-rac-glycerol in New Zealand obese (NZO) mice.1 The concentration of 1-stearoyl-3-oleoyl-rac-glycerol decreases from 4.59 to 1.88% during the dry-curing process of Iberian ham.2References1. Baumeier, C., Kaiser, D., Heeren, J., et al. Caloric restriction and intermittent fa...
T37284	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes.
T77228	Polyoxyethylene Sorbitan Monostearate
	Polyoxyethylene Sorbitan Monostearate 是一种由饱和脂肪酸硬脂酸 (C18:0) 构成的酯，广泛应用作药用辅料，包括表面活性剂、乳化剂、增溶剂和润湿剂。作为药用助剂，其主要作用是改善药物制剂的稳定性、溶解性和加工性，同时对药物的吸收、分布、代谢和消除 (ADME) 过程具有影响。
T38218	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 是一种在生物膜中的磷脂，在 sn-1 和 sn-2 位置分别含有硬脂酸和二十二碳六烯酸。它已被用于研究脂膜的组织和动力学。在超氧化物歧化酶 1 突变体转基因小鼠肌萎缩性脊髓侧索硬化症（ALS）模型中1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 的水平在疾病晚期会在 L5 前角下降。1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 可用于研究生物膜。
T36454	1-Stearoyl-rac-glycerol
	1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position. 1-Stearoyl-rac-glycerol levels are decreased in tumor tissue in a mouse model of azoxymethane-induced colorectal carcinogenesis. Levels of 1-stearoyl-rac-glycerol are decreased in lung tissue from patients with adenocarcinoma, but are increased in the serum of patients with Buruli ulcer and in the cerebrospinal fluid of patients with the inflammatory demyelinating diseases multiple sclerosis (MS), neur...

化合物

3-hydroxy Stearic Acid

Cat.No: T37681

Synonym: 3-hydroxystearic acid,3-hydroxyoctadecanoic acid

2-Hydroxystearic acid

Cat.No: T35684

Synonym: 2-Hydroxy stearic acid,DL-2-Hydroxystearic acid

2-chloro Stearic Acid

Cat.No: T37278

12-hydroxy Stearic Acid

Cat.No: T36456

Stearic acid-1-13C

Cat.No: T41254

Methyl stearic acid

Cat.No: T33343

2-hydroxy Stearic Acid methyl ester

Cat.No: T35703

Cat.No: T14186

Synonym: 17-十八炔酸,Alkynyl Stearic Acid

Target: Others, PROTAC Linker

12-oxo Stearic Acid methyl ester

Cat.No: T65291

Sorbitan monostearate

Cat.No: T20767

Synonym: Span 55,Emsorb 2505,Sorbon S 60,Liposorb S-20,Sorgen 50

Cat.No: T36590

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC

Cat.No: T37485

9,10-Dichlorostearic acid

Cat.No: T40663

Cat.No: T36142

1-Octadecyl Lysophosphatidic Acid

Cat.No: T36768

1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE

Cat.No: T38217

1,3-Distearoyl-2-Oleoyl-rac-glycerol

Cat.No: T38358

1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol

Cat.No: T35443

Cat.No: T36586

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC

Cat.No: T37486

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

Cat.No: T37487

1-Stearoyl-3-Oleoyl-rac-glycerol

Cat.No: T35445

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

Cat.No: T37284

Polyoxyethylene Sorbitan Monostearate

Cat.No: T77228

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC

Cat.No: T38218

1-Stearoyl-rac-glycerol

Cat.No: T36454

Cat. No.	Product Name	Target	Signaling Pathways
T2P2923	Stearic acid 硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid	Phosphatase; Endogenous Metabolite	Metabolism
	Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸，存在于许多动植物油脂中。
T37067	9-hydroxy Stearic Acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	9-hydroxy Stearic Acid 是一种羟基脂肪酸，是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时，可抑制HT-29细胞的增殖，并诱导细胞周期阻滞于G0/ g1期。
T2O2666	Methyl stearate Stearic Acid methyl ester,硬脂酸甲酯,Methyl Octadecanoate	Others	Others
	Methyl stearate (Methyl Octadecanoate) 是大豆和油菜籽生物柴油的组分，分离自 Rheum palmatumL 中。
T20091	Stearamide Stearic acid amide,NSC 66462,NSC66462,NSC-66462
	Stearamide(Stearic acid amide)是一种初级脂肪酸酰胺，具有细胞毒性和鱼类毒性,可用于增加纳米颗粒的性能。
T5249	1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine 1,2-DSPE,1,2-二硬酯酰-SN-甘油-3-磷酰乙醇胺,1,2-Distearoyl-sn-glycero-3-phosphoethan	Others; Endogenous Metabolite	Metabolism; Others
	1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE) 是一种磷脂酸乙醇胺 (PE) ，能够用于合成脂质体。
T4944	Nervonic acid cis-15-Tetracosenoic acid,神经酸,Selacholeic acid	Endogenous Metabolite	Metabolism
	Nervonic acid (Selacholeic acid) 是在髓磷脂生物合成中很重要的单不饱和脂肪酸。
T83876	L-Ascorbic Acid 6-stearate L-Ascorbyl-6-stearate,6-O-Stearoyl-L-Ascorbic Acid
	L-抗坏血酸6硬脂酸酯是L-抗坏血酸与硬脂酸的衍生物，在K. coccinea中发现，具有抗氧化和抗癌作用。在细胞外试验中清除DPPH（IC50 = 3.31 µg/ml）。包裹L-抗坏血酸6硬脂酸酯的脂质纳米颗粒（LNPs）在190 µM浓度下诱导HL-60前髓母细胞凋亡。含有L-抗坏血酸6硬脂酸酯的配方已用于化妆品和个人护理产品中。

天然产物

Stearic acid

Cat.No: T2P2923

Synonym: 硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid

Target: Phosphatase, Endogenous Metabolite

9-hydroxy Stearic Acid

Cat.No: T37067

Target: HDAC

Methyl stearate

Cat.No: T2O2666

Synonym: Stearic Acid methyl ester,硬脂酸甲酯,Methyl Octadecanoate

Target: Others

Cat.No: T20091

Synonym: Stearic acid amide,NSC 66462,NSC66462,NSC-66462

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

Cat.No: T5249

Synonym: 1,2-DSPE,1,2-二硬酯酰-SN-甘油-3-磷酰乙醇胺,1,2-Distearoyl-sn-glycero-3-phosphoethan

Target: Others, Endogenous Metabolite

Nervonic acid

Cat.No: T4944

Synonym: cis-15-Tetracosenoic acid,神经酸,Selacholeic acid

Target: Endogenous Metabolite

L-Ascorbic Acid 6-stearate

Cat.No: T83876

Synonym: L-Ascorbyl-6-stearate,6-O-Stearoyl-L-Ascorbic Acid

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