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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T81134	Sodium Channel inhibitor 4	Sodium Channel	Membrane transporter/Ion channel
	Sodium Channel Inhibitor4 是一种抑制钠通道的化合物。
T0916	Butamben Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯	Potassium Channel; Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Butamben (Butyl 4-aminobenzoate) 是一种长效局部麻醉剂，用于治疗慢性疼痛。
T7336	ICA-121431 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl	Sodium Channel	Membrane transporter/Ion channel
	ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) 是强效的、广谱的电压门控钠通道阻滞剂，对人 Nav1.1 和 Nav1.3 亚型具有等效选择性，IC50分别为 13 nM 和 23 nM。它对Nav1.2 的抑制作用较弱，IC50为240 nM，对 Nav1.4、Nav1.6、抗TTX 的人 Nav1.5、Nav1.8 通道表现出大于 1000 倍的选择性，IC50>10 μM。
T7349	Ralfinamide (S)-2-[[4-[(2-氟苄基)氧基]苄基]氨基]丙酰胺,Priralfinamide,FCE-26742A	Sodium Channel	Membrane transporter/Ion channel
	Ralfinamide (Priralfinamide) 是一种具有口服活性的，来源于 α-aminoamide 的钠离子通道阻滞剂, 在缓解疼痛方面有研究的价值。
T8579	Nav1.8-IN-1 5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamide,CHEMBL1270208	Sodium Channel	Membrane transporter/Ion channel
	Nav1.8-IN-1 (CHEMBL1270208) 是一种有效的 Na(v)1.8 钠通道抑制剂，可用于研究精神性疼痛及炎症性疼痛。
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

化合物

Sodium Channel inhibitor 4

Cat.No: T81134

Synonym:

Target: Sodium Channel

Butamben

Cat.No: T0916

Synonym: Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯

Target: Potassium Channel, Calcium Channel, Sodium Channel

ICA-121431

Cat.No: T7336

Synonym: 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl

Target: Sodium Channel

Ralfinamide

Cat.No: T7349

Synonym: (S)-2-[[4-[(2-氟苄基)氧基]苄基]氨基]丙酰胺,Priralfinamide,FCE-26742A

Target: Sodium Channel

Nav1.8-IN-1

Cat.No: T8579

Synonym: 5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamide,CHEMBL1270208

Target: Sodium Channel

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TN6713	6-Benzoylheteratisine Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth,苯甲酰新异乌头碱	Sodium Channel	Membrane transporter/Ion channel
	6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) 是乌头碱的拮抗剂，乌头碱是天然 Na+通道激活剂。