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Cat. No.	Product Name	Target	Signaling Pathways
T12979	BI-3406	p38 MAPK; MAPK; Ras	GPCR/G Protein; MAPK
	BI-3406 是一种可口服、高效且选择性的 KRAS-SOS1 抑制剂，具有抗癌活性。它有效减少 GTP 加载的 KRAS 的形成，抑制 MAPK 信号通路。它还抑制 KRAS 与 SOS1之间相互作用，IC50为 6 nM。
T39738	ASP2453	Ras	GPCR/G Protein; MAPK
	ASP2453是选择性的KRAS G12C 共价抑制剂，抑制Son of Sevenless 介导的KRAS G12C 和Raf 之间的相互作用，IC50为40 nM。
T61963	SOS1-IN-3
	SOS1-IN-3 是有效的SOS1抑制剂（IC50=5 nM）。SOS1-IN-3 显示出抗癌活性。
TP2116	SAH-SOS1A
	KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Display
T62003	SOS1-IN-13
	SOS1-IN-13 是有效的SOS1抑制剂。SOS1-IN-13抑制 SOS1 和 pERK 的IC50分别为 6.5 nM 和 327 nM。SOS1-IN-13 在抗癌研究中具有一定的价值。
T37422	Ras Inhibitory Peptide
	Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction ...