Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0272 |
Nilutamide
尼鲁米特,RU23908 |
Androgen Receptor | Endocrinology/Hormones |
Nilutamide (RU23908) 是一种非甾体抗雄激素药物,有用于转移性前列腺癌的潜力。 | |||
T12770 |
RR-11a analog
aza-peptide Michael acceptor, 7a |
Parasite | Microbiology/Virology |
RR-11a analog (aza-peptide Michael acceptor, 7a) 是一种天冬酰胺酰内肽酶抑制剂,对阴道毛滴虫中的 AE1、蓖麻硬蜱中的 AE 和曼氏血吸虫中的 AE 的 IC50 分别为 4.5 nM、4.5 nM 和 31 nM。 | |||
T61549 | HDAC8-IN-2 | ||
HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 μM and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. It effectively kills schistosome larvae and greatly reduces egg laying in adult worm pairs [1]. | |||
T34809 |
Teroxalene hydrochloride
Teroxalene HCl,NSC 138704 |
||
Teroxalene Hydrochloride is disubstituted piperazine used to treat animals with Schistosoma mansoni. | |||
T69421 |
Hydrolapachol
|
||
Hydrolapachol is a novel potent and selective inhibitor of schistosoma mansoni dihydroorotate dehydrogenase (smdhodh) | |||
T33957 |
PF-Alkyne
PF Alkyne |
||
PF-Alkyne is a fluorophosphonate-based probe which specifically and covalently reacts with the tyrosine-111 residue of the Schistosoma japonicum GST (sjGST) tag. PF-Alkyne rapidly and site-selectively immobilizes sjGST fusion proteins. | |||
T61538 |
Antiparasitic agent-10
|
||
Antiparasitic agent-10 (Compound 94) is a potent anti-parasitic agent specifically designed to target and combat parasitic infections. It demonstrates notable anti-schistosomal activity, particularly against adults of Schistosoma mansoni. As a result, this compound holds significant potential for utilization in Schistosomiasis research as a viable treatment option [1]. | |||
T78391 |
DAUDA
|
||
DAUDA (11-(dansylamino) undecanoic acid)是一种荧光脂肪酸类似物,对环境变化敏感。该分子通过调整其发射强度和荧光光谱与结合蛋白发生相互作用。在研究中,DAUDA用于评估天然脂肪酸与曼氏血吸虫Sm14脂肪酸结合蛋白多晶型的相对亲和力。 | |||
T78619 |
Z-Pro-Pro-CHO
|
Prolyl Endopeptidase (PREP) | Metabolism; Proteases/Proteasome |
Z-Pro-Pro-CHO为一种有效的脯氨酰寡肽酶抑制剂,其具有针对人类及曼氏血吸虫脯氨酰寡肽酶的较低半抑制浓度(IC50),分别为0.16 μM和0.01 μM。 |