Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12928 |
SK33
|
Androgen Receptor | Endocrinology/Hormones |
SK33 是一种有效的组织选择性抗雄激素药物,是一种肌醇类似物,能够降低雄激素受体 (AR) 的转录活性。 | |||
T5745 |
GSK3326595
EPZ015938 |
Histone Methyltransferase | Chromatin/Epigenetic |
GSK3326595 (EPZ015938) 是一种选择性可逆的蛋白精氨酸甲基转移酶 5 抑制剂,IC50为6.2 nM,具有广谱的抗增殖活性。 | |||
T11500L |
GSK3368715 dihydrochloride
EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl |
Histone Methyltransferase | Chromatin/Epigenetic |
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) 是一种具有口服活性和高效性的 I 型蛋白精氨酸甲基转移酶 (PRMTs) 抑制剂 ,具有抗癌和抗肿瘤活性,抑制PRMT1,PRMT3,PRMT4,PRMT6,PRMT8的活性,可用于研究晚期实体肿瘤。 | |||
T22342 |
GSK3368715 3HCl
EPZ019997 3HCl,GSK3368715(EPZ019997) |
Histone Methyltransferase | Chromatin/Epigenetic |
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM. | |||
T15439 |
GSK3395879
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4). | |||
T11500 |
GSK3368715
EPZ019997 |
Histone Methyltransferase | Chromatin/Epigenetic |
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). It has strong anti-cancer activity. | |||
T27473 |
GSK334429
GSK-334429,GSK 334429 |
||
GSK334429 is an antagonist of histamine H3 receptor. |