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Targets Recommended: TGF-beta/Smad

2

抑制剂 & 化合物

4

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T3636 (E)-SIS3

SIS3,SIS3 盐酸盐,SIS3 HCl

TGF-beta/Smad Stem Cells
(E)-SIS3 (SIS3) 是 Smad3 的选择性抑制剂,能够抑制 Smad3 磷酸化(IC50:3 μM)。它利用 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。
T70083 Cilengitide hydrochloride

Cilengitide hydrochloride sis the salt form of Cilengitide, a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.

化合物

(E)-SIS3
Cat.No: T3636
Synonym: SIS3,SIS3 盐酸盐,SIS3 HCl
Target: TGF-beta/Smad
Cilengitide hydrochloride
Cat.No: T70083
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-04644 PDGFB Protein, Human, Recombinant (His)

platelet-derived growth factor beta polypeptide,SSV...

Human P. pastoris (Yeast)
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted...
TMPY-04877 PDGFB Protein, Mouse, Recombinant (His)

platelet-derived growth factor β polypeptide,血小板源生长因子,Si...

Mouse P. pastoris (Yeast)
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted...
TMPH-02567 CCL4 Protein, Mouse, Recombinant (His)

Immune activation protein 2,SIS-gamma,Mip1b,MIP-1-<...

Mouse E. coli
Monokine with inflammatory and chemokinetic properties.
TMPJ-00005 CCL3 Protein, Human, Recombinant

MIP-1-Alpha,CCL3,MIP-1-α,Small-Inducible Cytokine A3,C-C Mot...

Human E. coli
Human Chemokine (C-C Motif) Ligand 3 (CCL3) is a small cytokine belonging to the CC chemokine family. CCL3 is primarily expressed in T cells, B cells, and monocytes after antigen or mitogen stimulation. CCL3 exhibits chemoattractive and adhesive effects on lymphocytes. CCL3 exerts multiple effects on hematopoietic precursor cells and inhibits the proliferation of hematopoietic stem cells in vitro as well as in vivo. CCR1 and CCR5 have been identified as functional receptors for CCL3.

重组蛋白

PDGFB Protein, Human, Recombinant (His)
Cat.No: TMPY-04644
Species: Human
Expression System: P. pastoris (Yeast)
PDGFB Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04877
Species: Mouse
Expression System: P. pastoris (Yeast)
CCL4 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02567
Species: Mouse
Expression System: E. coli
CCL3 Protein, Human, Recombinant
Cat.No: TMPJ-00005
Species: Human
Expression System: E. coli
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