Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24793 |
SIRT6-IN-5
SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT6-IN-5(SIRT6 inhibitor 5) 是一种具有有效性和选择性的 SIRT6 抑制剂 ,IC50 值为 34 μM。SIRT6-IN-5 具有免疫抑制和化疗增敏作用,可增加 H3K9 的乙酰化并增加培养细胞中的葡萄糖摄取,减少 T 细胞增殖。 | |||
T4328 |
OSS_128167
SIRT6-IN-1 |
HBV; Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
OSS_128167 (SIRT6-IN-1) 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂,对 SIRT6,SIRT1 和 SIRT2 的 IC50分别为 89 μM,1578 μM 和 751 μM。它具有抗 HBV、抗癌、抗炎和抗病毒活性,可抑制 HBV 的转录和复制。 | |||
T28784 |
SIRT6-IN-1
|
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SIRT6-IN-1, a novel SIRT6 inhibitor, reduces glycemia and improves oral glucose tolerance in unfed wild-type mice. | |||
T72484 |
SIRT6 activator 12q
|
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SIRT6 activator12q是一种有效、选择性且口服活性SIRT6激活剂,其对SIRT1、SIRT2、SIRT3、SIRT5、SIRT6的IC50值依次为171.20、>200、>200、>200、0.58 μM。该化合物能够抑制细胞增殖和迁移,同时诱导细胞凋亡(Apoptosis)及在G2期引起细胞周期停滞,展现了其抗癌潜力。 | |||
T79689 |
SIRT6-IN-3
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT6-IN-3 (compound 8a) 作为SIRT6的选择性抑制剂,其IC50值为7.49 μM。该化合物能有效抑制胰腺导管腺癌 (PDAC) 细胞的增殖,并诱导细胞凋亡。SIRT6-IN-3 通过抑制 DNA 损伤的修复作用,增强了吉西他滨对癌细胞的敏感性,常用于胰腺癌相关研究。 | |||
T7679 |
UBCS039
|
Sirtuin; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
UBCS039 是一种合成的 SIRT6特异性激活剂,可在人癌细胞中诱导自噬,其 EC50值为38 μM。 | |||
T64529 |
MDL-800
MDL 800,MDL800 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT6, responsible for deacetylation of histone H3 Nε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac), is a tumor suppressor which has frequently been found to have low expression in various cancers. MDL-800 is a selective SIRT6 activator. It increased the deacetylase activity of SIRT6 by up to 22-fold and led to a global decrease in H3K9ac and H3K56ac levels in human hepatocellular carcinoma (HCC) cells. Also, it inhibited the proliferation of HCC cells via SIRT6-driven cell-cycle arrest and was eff... | |||
T75107 | CrBKA | ||
CrBKA 是SIRT6的弱活性荧光小分子底物。 | |||
T81831 |
MDL-811
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
MDL-811为SIRT6的异构激活剂,有效促进SIRT6对组蛋白H3的去乙酰化作用(H3K9Ac, H3K18Ac, 和 H3K56Ac)。该化合物在结肠癌研究中有应用价值。 | |||
T69707 | MDL-801 | ||
MDL-801 is an activator of SIRT6 deacetylation. |