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Cat. No. Product Name Target Signaling Pathways
T71947 SGK1 inhibitor

SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719.
T9977 SGK1-IN-4

SGK Metabolism
SGK1-IN-4 是 SGK1 的特异性抑制剂,可用于骨关节炎研究。
T9589 SI-113

SGK Metabolism
SI-113 是一种有效的选择性 SGK1 抑制剂,SGK1 是一种丝氨酸/苏氨酸蛋白激酶,可调节多种致癌信号级联反应。
T12890 SGK1-IN-1

Others Others
SGK1-IN-1 is a highly active and selective SGK-1 inhibitor(IC50 of 1 nM).
T11181 EMD638683 R-Form

SGK Metabolism
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.
T12891 SGK1-IN-2

Others Others
SGK1-IN-2 (14h) is a selective inhibitor of SGK1 (serum and glucocorticoid regulated kinase 1)(with an IC50 of 5 nM at 10 μM ATP concentration).
T11182 EMD638683 S-Form

Others Others
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 S-Form is the S-form of EMD638683.
T63741 SGK1-IN-3

SGK1-IN-3 是有效的、口服具有活力的 SGK1 抑制剂。其中丝氨酸/苏氨酸激酶 SGK1 是 β-连环蛋白途径的激活剂,也是强大的软骨降解刺激剂,在患病的骨关节炎软骨中被发现在基因组控制下被上调。SGK1-IN-3 对骨关节炎表现出研究潜力。

化合物

SGK1 inhibitor
Cat.No: T71947
Synonym:
Target:
SGK1-IN-4
Cat.No: T9977
Synonym:
Target: SGK
SI-113
Cat.No: T9589
Synonym:
Target: SGK
SGK1-IN-1
Cat.No: T12890
Synonym:
Target: Others
EMD638683 R-Form
Cat.No: T11181
Synonym:
Target: SGK
SGK1-IN-2
Cat.No: T12891
Synonym:
Target: Others
EMD638683 S-Form
Cat.No: T11182
Synonym:
Target: Others
SGK1-IN-3
Cat.No: T63741
Synonym:
Target:
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