Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71947 |
SGK1 inhibitor
|
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SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719. | |||
T9977 |
SGK1-IN-4
|
SGK | Metabolism |
SGK1-IN-4 是 SGK1 的特异性抑制剂,可用于骨关节炎研究。 | |||
T9589 |
SI-113
|
SGK | Metabolism |
SI-113 是一种有效的选择性 SGK1 抑制剂,SGK1 是一种丝氨酸/苏氨酸蛋白激酶,可调节多种致癌信号级联反应。 | |||
T12890 | SGK1-IN-1 | Others | Others |
SGK1-IN-1 is a highly active and selective SGK-1 inhibitor(IC50 of 1 nM). | |||
T11181 | EMD638683 R-Form | SGK | Metabolism |
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683. | |||
T12891 | SGK1-IN-2 | Others | Others |
SGK1-IN-2 (14h) is a selective inhibitor of SGK1 (serum and glucocorticoid regulated kinase 1)(with an IC50 of 5 nM at 10 μM ATP concentration). | |||
T11182 |
EMD638683 S-Form
|
Others | Others |
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 S-Form is the S-form of EMD638683. | |||
T63741 | SGK1-IN-3 | ||
SGK1-IN-3 是有效的、口服具有活力的 SGK1 抑制剂。其中丝氨酸/苏氨酸激酶 SGK1 是 β-连环蛋白途径的激活剂,也是强大的软骨降解刺激剂,在患病的骨关节炎软骨中被发现在基因组控制下被上调。SGK1-IN-3 对骨关节炎表现出研究潜力。 |