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2

抑制剂 & 化合物

6

天然产物

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Cat. No. Product Name Target Signaling Pathways
T36408 Rhein-13C4

Rhein-13C4

Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...
T35975 6,9-Dichloro-1,2,3,4-tetrahydroacridine

6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylchol...

化合物

Rhein-13C4
Cat.No: T36408
Synonym: Rhein-13C4
Target:
6,9-Dichloro-1,2,3,4-tetrahydroacridine
Cat.No: T35975
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T2997 Rhein

Rheinic Acid,Monorhein,大黄酸,NSC 38629,Rheic Acid,Rhubarb yellow

Reactive Oxygen Species; Antibacterial; Autophagy Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
Rhein (NSC 38629) 从蓼科大黄中提取的一种蒽醌类化合物,有抗炎、抗氧化、抗癌等作用。
TN2154 Rhein 8-Glucoside

大黄酸-8-葡糖苷,Rhein-8-glucoside,大黄酸 8-葡糖苷

Others Others
Rhein 8-Glucoside (Rhein-8-glucoside) 是一种蒽醌糖苷,存在于大黄(rhubarb) 中,显示出泻下活性。
T3827 Rhein-8-glucoside calcium

大黄酸-8-O-β-D-葡萄糖苷,Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt

Phosphatase; Antibacterial Metabolism; Microbiology/Virology
Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt 是一种从 Saussurea lappa 根的 EtOH 提取物中,分离得到的蒽醌类 hPTP1B 抑制剂,IC50值为11.5 μM,具有抗菌作用。
TN3435 Aporheine

Others Others
Aporheine is a natural product from Phellinus igniarius.
T1273 Diacerein

双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein

IL Receptor; Interleukin Immunology/Inflammation
Diacerein (Fisiodar) 是一种慢效具有白介素-1β 抑制效果的蒽醌类化合物。
TN2278 Torachrysone

决明柯酮

Antifection Microbiology/Virology
Torachrysone shows promising antioxidant activity. Torachrysone, toralactone , aloe-emodin, rhein and emodin show noticeable antibacterial effects on four strains of methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 2-

天然产物

Rhein
Cat.No: T2997
Synonym: Rheinic Acid,Monorhein,大黄酸,NSC 38629,Rheic Acid,Rhubarb yellow
Target: Reactive Oxygen Species, Antibacterial, Autophagy
Rhein 8-Glucoside
Cat.No: TN2154
Synonym: 大黄酸-8-葡糖苷,Rhein-8-glucoside,大黄酸 8-葡糖苷
Target: Others
Rhein-8-glucoside calcium
Cat.No: T3827
Synonym: 大黄酸-8-O-β-D-葡萄糖苷,Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt
Target: Phosphatase, Antibacterial
Aporheine
Cat.No: TN3435
Synonym:
Target: Others
Diacerein
Cat.No: T1273
Synonym: 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein
Target: IL Receptor, Interleukin
Torachrysone
Cat.No: TN2278
Synonym: 决明柯酮
Target: Antifection
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