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6

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3561	CPI1189 CPI-1189,REN-1189,CPI 1189	TNF	Apoptosis
	CPI1189 (REN-1189) 是 TNF-α 释放抑制剂，具有神经保护作用及抗氧化作用。它可用于研究 HIV 相关神经毒性，具有成为 HIV 相关 CNS 疾病患者神经保护治疗药物的潜能。
T12703	ReN-1869 hydrochloride NNC-05-1869 hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	ReN 1869 hydrochloride is a novel, selective antagonist of histamine H1 receptor.
T28516	ReN-1869 NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869
	ReN-1869 is a histamine H1 receptor antagonist. ReN 1869 is active against inflammation and neurogenic pain. ReN-1869 produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and neuropathy.
T70856	3-Oxobetulin Acetate
	3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblasto...
T35855	AAA
	AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension...
T35787	Obestatin (human) (trifluoroacetate salt)
	Obestatin is a 23 amino acid peptide hormone with a conserved C-terminal glycine residue and amidation site that is formed by cleavage of the ghrelin and obestatin prepropeptide.1It binds to the orphan receptor GPR39 (Kd= 1 nM) and stimulates cAMP production in CHO and HEK293 cells overexpressing human GPR39. Obestatin inhibits contraction of isolated mouse jejunum muscle strips induced by ghrelin .In vivo, obestatin (12.5-1,000 nmol/kg) suppresses food intake in a time- and dose-dependent manne...

化合物

Cat.No: T3561

Synonym: CPI-1189,REN-1189,CPI 1189

Target: TNF

ReN-1869 hydrochloride

Cat.No: T12703

Synonym: NNC-05-1869 hydrochloride

Target: Histamine Receptor

Cat.No: T28516

Synonym: NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869

3-Oxobetulin Acetate

Cat.No: T70856

Cat.No: T35855

Obestatin (human) (trifluoroacetate salt)

Cat.No: T35787

Cat. No.	Product Name	Target	Signaling Pathways
TL0002	Liquiritin apioside	Others	Others
	Liquiritin apioside 是一种从甘草中获得的黄酮，具有镇咳活性。

天然产物

Liquiritin apioside

Cat.No: TL0002

Target: Others

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