Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5513 |
RO-3
|
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
RO3 是一种能透过大脑的P2X3和P2X2/3拮抗剂,口服有活性。它对人同型多聚体 P2X3和异型多聚体 P2X2/3受体的 pIC50分别为 5.9 和 7.0。 | |||
T30611 |
Bufuralol
Ro3-4787,Ro 3-4787,Ro-3-4787 |
||
Bufuralol is a Adrenergic Agent. | |||
TP2206 |
[Leu31,Pro34]-Neuropeptide Y (porcine)
LEU 31, PRO34]-神经肽Y(猪) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
[Leu31,Pro34]- Neuropeptide Y (porcine) 是神经肽 Y (NPY) 的一种类似物,是对NPY Y1受体有选择性的激动作用。它表现出抗焦虑作用。 | |||
TP2020L |
[Pro3]-GIP (Mouse) acetate
|
Others | Others |
[Pro3]-GIP (Mouse) acetate 是鼠源[Pro3]-GIP。[Pro3]-GIP 是一种 GIP receptor 拮抗剂。 | |||
T69360 |
RO3244794
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
RO3244794是一种具有选择性的前列环素 (IP)受体拮抗剂,可用于研究肝脏损伤。 | |||
T2634 |
Ro3280
RO 3280,Ro5203280 |
PLK | Cell Cycle/Checkpoint |
Ro3280 (Ro5203280) 是一种高度选择性的PLK1抑制剂,IC50和Kd 值分别为 3 nM 和 0.09 nM。 | |||
T76313 |
(Pro3) GIP, human
|
||
(Pro3) GIP, human ((Pro3)Gastric Inhibitory Peptide, human) 是一种有效、稳定和特异性的人 GIP 受体完全激动剂。(Pro3) GIP, human 对人 GIPR 具有高结合亲和力,Ki/ Kd 值为 0.90 nM。(Pro3) GIP, human 可用于肥胖相关糖尿病的研究。 | |||
T76441 |
(Pro34)-Peptide YY (human)
|
||
(Pro34)-Peptide YY (human) 是 Peptide YY/neuropeptide Y 受体的高度 Y1选择性全激动剂。 | |||
T34370 |
RO320-2947/001
RO-320-2947/001,RO 320-2947/001 |
||
RO320-2947/001 is a bioactive chemical. | |||
TP2021 |
[Pro3]-GIP (Rat)
|
||
High affinity rat GIP receptor partial agonist (Kd = 13 nM). Increases cAMP accumulation in COS-7 cells transfected with rat GIP receptor, while also acting as a competitive antagonist of GIP. | |||
T75912 |
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA
|
||
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 是一种针对神经肽 YY1受体的特定激动剂,并亦能够激活Y4和Y5受体。该化合物能提高麻醉大鼠的血压并增加食物摄入。 | |||
TP1985 |
[Leu31,Pro34]-Neuropeptide Y(human,rat)
[Leu31,Pro34]-Neuropeptide Y (human, rat) |
||
High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors. | |||
TP2020 |
[Pro3]-GIP (Mouse)
|
||
GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insul | |||
T34903 |
TO-PRO3 iodide
TOPRO3 iodide,TO-PRO3 iodide salt |
||
TO-PRO3 iodide is a nucleic acid stain that can stain the nucleus of cells in different states, including living, early apoptotic, and necrotic cells. | |||
T71420 | RO314724 | ||
RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants. | |||
T83499 |
[D-Phe2,6, Pro3]-LH-RH
|
||
[D-Phe2,6, Pro3]-LH-RH是一种促黄体生成素释放激素(LHRH)的高效拮抗剂,具有特定氨基酸序列变异。 | |||
T80087 |
(Leu31,Pro34)-Peptide YY (human) (TFA)
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
'(Leu31,Pro34)-Peptide YY (human)(TFA)' 为 '(Leu31,Pro34)-Peptide YY (human)' 的 TFA 盐形式,该化合物为 Peptide YY 的衍生物,兼具高效和选择性的 Y1 受体激动剂特性,其 KD 值为 1.0 nM。 | |||
T76442 |
(Leu31,Pro34)-Peptide YY (human)
|
||
(Leu31,Pro34)-Peptide YY (human) 是一种 Peptide YY 的衍生物,是一种有效的、选择性的 Y1激动剂,KD 为 1.0 nM。 |