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Cat. No.	Product Name	Target	Signaling Pathways
T3185	R112 (E)-Elafibranor	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	R112 ((E)-Elafibranor) 是ATP 竞争性的 Syk 激酶抑制剂，它能够抑制Syk 激酶活性，Ki=6 nM，IC50=226 nM。
T10965	DBPR112	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	DBPR112 是一种口服有效的基于氟嘧啶的 EGFR 抑制剂，对 EGFRWT 和 EGFRL858R/T790M 的 IC50 分别为 15 nM 和 48 nM。DBPR112 可以占据 ATP 结合位点。DBPR112 具有显着的抗肿瘤功效。
T23383	SR11237 SR 11237	Others; RAR/RXR	Metabolism; Others
	SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。
T69498	DBPR112 HCl
	DBPR112 is a potent EGFR inhibitor (IC50=487 nM) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. DBPR112), DBPR112 not only displayed a potent inhibitory activity against EGFRL858R/T790M double mutations but also exhibited tenfold potency better than the third-generation inhibitor, osimertinib,against EGFR and HER2 exon 20 insertion mutations. Overall, pharmacokinetic improvement through lead-to-candidate optimization yielded fourfold oral AUC better that afatinib alon...