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15

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T71552	ASC-JM-17
	ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies.
T1309	Propylthiouracil 丙硫氧嘧啶,Pseudocapsaicin,NSC 6498,丙基硫氧嘧啶,NSC 70461,6-n-Propylthiouracil,6-Propyl-2-thiouracil	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Propylthiouracil (6-n-Propylthiouracil) 是一种甲状腺过氧化物酶抑制剂，也是一种5'-脱碘酶抑制剂。
T4132	BPTU BMS-646786	P2Y Receptor	GPCR/G Protein; Neuroscience
	BPTU (BMS-646786) 是一种非核苷酸类P2Y1受体变构拮抗剂，能够阻断位于胃肠道神经肌肉接头的 P2Y1受体，具有抗血栓活性。
T12580	PTUPB	COX; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Neuroscience
	PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。
T33881	Paracetamol mercapturate
	Paracetamol mercapturate is a deuterated metabolite of acetaminophen.
T20215	Acetaminophen mercapturate
	Paracetamol Mercapturate is a metabolite of Acetaminophen. It can also be used in the biological study of urinary antihypertensive drugs.
T73940	S-Phenylmercapturic acid
	S-Phenylmercapturic acid，苯的代谢物，作为生物标志物使用，可通过GC、HPLC（UV或荧光检测）、GC-MS、LC-MS/MS或免疫测定进行检测。
T33924	Pentylmercapturic acid
	Pentylmercapturic acid is a bioactive chemical.
T33912	Pentachlorophenylmercapturic acid
	Pentachlorophenylmercapturic acid is a bioactive chemical.
T35971	4-hydroxy Nonenal Mercapturic Acid
	Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates. The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remain...
T37989	D-Sedoheptulose-7-phosphate (barium salt)
	D-Sedoheptulose-7-phosphate is an intermediate in the pentose phosphate pathway. [1] [2] In this pathway, transaldolase catalyzes the transfer of a three carbon dihydroxyacetone moiety from D-sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to generate D-fructose-6-phosphate . D-Sedoheptulose-7-phosphate is also an intermediate in carbon fixation in photosynthetic organisms, as well as in the biosynthesis of lipopolysaccharide, amino acids, secondary metabolites, and antibiotics. [3]
T30976	Clofibrate mercapturate
	Clofibrate mercapturate is a urinary metabolite of clofibrate.
T81704	Naptumomab
	Naptumomab是一种针对肿瘤细胞的超级抗原(TTS)融合蛋白。它能激活免疫系统，使之识别并消灭肿瘤细胞。该化合物主要应用于肾细胞癌等难治性实体肿瘤的研究领域。
T36469	Atrazine Mercapturate
	Atrazine mercapturate is a major, glutathione-derived metabolite of atrazine , an herbicide that is effective in controlling a broad range of weeds. Atrazine has been reported to cause cancer in certain laboratory animals, have diverse effects on the reproductive system in animals and humans, and disrupt the normal function of the endocrine system. Atrazine mercapturate is readily measured in urine samples.
T66029	3,4-Dehydro-L-proline
	The leguminous shrub,Leucaena leucocephala(Leucaena) is wide‐spread in tropical and subtropical agricultural systems and provides a ready source of protein for livestock. However, the presence of mimosine, a non‐protein, amino acid comprising about 12% of the dry matter in growing tips ofLeucaena, is toxic to animals. Mimosine is degraded rapidly in the rumen to produce 3,4‐dihydroxypyridine (3,4‐DHP) and 2,3‐dihydroxypyridine (2,3‐DHP), both of which remain toxic to animals[1]. 3,4-DHP, as a de...

化合物

Cat.No: T71552

Propylthiouracil

Cat.No: T1309

Synonym: 丙硫氧嘧啶,Pseudocapsaicin,NSC 6498,丙基硫氧嘧啶,NSC 70461,6-n-Propylthiouracil,6-Propyl-2-thiouracil

Target: Thyroid hormone receptor(THR)

Cat.No: T4132

Synonym: BMS-646786

Target: P2Y Receptor

Cat.No: T12580

Target: COX, Epoxide Hydrolase

Paracetamol mercapturate

Cat.No: T33881

Acetaminophen mercapturate

Cat.No: T20215

S-Phenylmercapturic acid

Cat.No: T73940

Pentylmercapturic acid

Cat.No: T33924

Pentachlorophenylmercapturic acid

Cat.No: T33912

4-hydroxy Nonenal Mercapturic Acid

Cat.No: T35971

D-Sedoheptulose-7-phosphate (barium salt)

Cat.No: T37989

Clofibrate mercapturate

Cat.No: T30976

Cat.No: T81704

Atrazine Mercapturate

Cat.No: T36469

3,4-Dehydro-L-proline

Cat.No: T66029

Cat. No.	Product Name	Target	Signaling Pathways
T10940	D-Mannoheptulose	Others	Others
	D-mannoheptose is the main non-structural carbohydrate in avocado. D-mannoheptose is a specific inhibitor of D-glucose phosphorylation. D-mannoheptose can prevent the release of insulin and the utilization of carbohydrates in rats.
T19268	D-Sedoheptulose 7-phosphate	Others	Others
	D-Sedoheptulose 7-phosphate is a common precursor of heptaic acid (group III) and hygromycin B (group IV) heptasaccharide. D-heptadecane 7-phosphate can be converted to NDP-heptose by similar biosynthetic pathways in these compounds.
TN7080	D-altrofurano-heptulose-3 alpha-D-Altro-3-heptulofuranose,D-阿卓-呋喃庚酮糖	Others	Others
	D-altrofurano-heptulose-3 (alpha-D-Altro-3-heptulofuranose) 从猕猴桃 (Rupr. & Maxim.) Maxim., 猕猴桃科的根茎中分离得到。
TN7007	Sedoheptulose anhydride monohydrate
	Sedoheptulose anhydride monohydrate is a natural product.

天然产物

D-Mannoheptulose

Cat.No: T10940

Target: Others

D-Sedoheptulose 7-phosphate

Cat.No: T19268

Target: Others

D-altrofurano-heptulose-3

Cat.No: TN7080

Synonym: alpha-D-Altro-3-heptulofuranose,D-阿卓-呋喃庚酮糖

Target: Others

Sedoheptulose anhydride monohydrate

Cat.No: TN7007

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