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Search Results for " ptpn1 "

Targets Recommended: Phosphatase

1

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T79049	Tegeprotafib PTPN2/1-IN-1	Phosphatase	Metabolism
	Tegeprotafib (PTPN2/1-IN-1) 是一种可口服活性PTPN1和PTPN2抑制剂，PTPN2的IC50为4.4 nM，PTPN1B的IC50介于1-10 nM之间。

化合物

Cat.No: T79049

Synonym: PTPN2/1-IN-1

Target: Phosphatase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04125	PTP1B Protein, Human, Recombinant (His) protein tyrosine phosphatase, non-receptor type 1,P...	Human	E. coli
	PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p...
TMPY-03486	PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST) PTPG1,protein tyrosine phosphatase, non-receptor ty...	Human	Baculovirus-Insect Cells
	PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN12 contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. PTPN12 was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenes...
TMPY-03548	PTPN12 Protein, Human, Recombinant protein tyrosine phosphatase, non-receptor type 12,...	Human	Baculovirus-Insect Cells
	PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN12 contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. PTPN12 was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenes...
TMPH-02277	PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)	Human	E. coli
	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification.

重组蛋白

PTP1B Protein, Human, Recombinant (His)

Cat.No: TMPY-04125

Species: Human

Expression System: E. coli

PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST)

Cat.No: TMPY-03486

Species: Human

Expression System: Baculovirus-Insect Cells

PTPN12 Protein, Human, Recombinant

Cat.No: TMPY-03548

Species: Human

Expression System: Baculovirus-Insect Cells

PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)

Cat.No: TMPH-02277

Species: Human

Expression System: E. coli

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