Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T34168 |
PROTAC-I
PROTAC I |
||
PROTAC-I targets steroid hormone receptors for ubiquitination and degradation. | |||
T13086 |
I-BET762 carboxylic acid
Molibresib carboxylic acid,PROTAC BRD4-binding moiety 2,GSK525762A carboxylic acid |
Epigenetic Reader Domain | Chromatin/Epigenetic |
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1). | |||
T40000 |
Pomalidomide-C3-I
|
Others | Others |
Pomalidomide-C3-I 是一种合成的 E3 连接酶配体-接头偶联物,它结合了 PROTAC 技术中使用的基于 Pomalidomide 的 CRBN 配体和接头。 | |||
T40008 |
Pomalidomide-C6-I TFA
|
Others | Others |
Pomalidomide-C6-I TFA 是一种合成的 E3 连接酶配体-接头偶联物,它结合了 PROTAC 技术中使用的基于 Pomalidomide 的 CRBN 配体和接头。 | |||
T39901 |
PROTAC IRAK4 degrader-4
PROTAC IRAK4 degrader-4 |
||
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T74411 |
PROTAC IRAK4 degrader-7
|
PROTACs | PROTAC |
PROTACIRAK4 degrader-7 (Compound I-417) 是一种具有口服活性的 PROTACIRAK4降解剂,具有抗肿瘤效果。 | |||
T39315 |
I-PEG5-OH
I-PEG5-OH |
||
I-PEG5-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T39679 |
Lenalidomide-I
|
||
Lenalidomide-I (Compound 72) is a derivative of the cereblon (CRBN) ligand, Lenalidomide, with affinity for E3 ubiquitin ligase. It facilitates the recruitment of CRBN protein. Lenalidomide-I can be utilized in PROTACs, such as the PROTAC BET degrader QCA570, by linking it to the targeted protein ligand through a linker. | |||
T38772 |
I-PEG6-OH
I-PEG6-OH |
||
I-PEG6-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T74455 |
JPS035
|
||
JPS035 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS035 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS035 是一种有效的 HDAC1/2 降解剂,与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。 | |||
T74456 |
JPS036
|
||
JPS036 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS036 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS036 是一种有效的 HDAC1/2 降解剂,与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。 | |||
T77938 |
JPS016 TFA
|
HDAC; PROTACs | Chromatin/Epigenetic; DNA Damage/DNA Repair; PROTAC |
JPS016 TFA是一种苯甲酰胺基Von Hippel-Lindau (VHL) E3连接酶蛋白水解靶向嵌合体(PROTAC)。该化合物能够降解I类组蛋白脱乙酰酶(HDAC),特别是有效地降解HDAC1/2。在HCT116细胞中,JPS016 TFA与大量差异基因表达增加及细胞凋亡(apoptosis)激活相关。 | |||
T74453 | JPS014 | ||
JPS014, 基于苯甲酰胺的Von Hippel-Lindau (VHL) E3-连接酶蛋白水解靶向嵌合体 (PROTAC),有效降解I 类组蛋白脱乙酰酶 (HDAC)。它作为HDAC1/2的强效降解剂,与HCT116细胞中的总差异表达基因更大和增强的细胞凋亡 (apoptosis) 密切相关。 | |||
T74454 |
JPS016
|
||
JPS016 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS016 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS016 是一种有效的 HDAC1/2 降解剂,与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。 | |||
T77937 |
JPS014 TFA
|
HDAC; PROTACs | Chromatin/Epigenetic; DNA Damage/DNA Repair; PROTAC |
JPS014 TFA是一种VHL E3连接酶蛋白水解靶向嵌合体(PROTAC),以苯甲酰胺为基础,专门降解I类组蛋白脱乙酰酶(HDAC)。作为一种高效的HDAC1/2降解剂,JPS014 TFA与HCT116细胞中广泛的基因表达差异及促进细胞凋亡(apoptosis)密切相关。 | |||
T78956 |
PROTAC BRD3/BRD4-L degrader-2
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
PROTACBRD3/BRD4-L degrader-2 是一款可以特异性地降解BRD3和BRD4-L的PROTAC分子,其对BRD3的Ki值为16.91 nM,对BRD4-L为2.8 nM。在小鼠异种移植模型中,该分子展示了卓越的抗肿瘤效果,可被应用于癌症相关研究。 | |||
T79034 |
GXF-111
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
GXF-111是一种PROTAC分子,能够选择性促进BRD3与BRD4-L在细胞内的降解。该分子与BRD3BD1和BRD3BD2的结合亲和力显著,Ki值分别为11.97 nM和2.35 nM。GXF-111主要用于癌症研究领域。 |