Cat. No. | Product Name | Target | Signaling Pathways |
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T23498 |
UNC3230
UNC 3230 |
Others | Others |
UNC3230 是一种 ATP 竞争性的磷脂酰肌醇 4 磷酸 5 激酶 1C 型 (PIP5K1C) 选择性抑制剂,其IC50约为 41 nM。它还可抑制PIP4K2C,但对其他调节磷酸肌醇水平的脂质激酶无抑制作用。它具有缓解疼痛和抗癌特性。 | |||
T70683 |
NA 382
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NA 382 is a staurosporine derivative that inhibits multidrug resistance. | |||
T15375 |
Inavolisib
GDC-0077,RG6114 |
Apoptosis; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
Inavolisib (GDC-0077) 是一种可口服的选择性PI3Kα抑制剂,IC50值为0.038 nM。Inavolisib 通过与 PI3K 的 ATP 结合位点结合而发挥其活性,从而抑制了 PIP2 到 PIP3 的磷酸化。 | |||
TP1977 |
187-1, N-WASP inhibitor
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Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization | |||
TP1948 |
PBP10
PBP 10 |
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Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exh | |||
TP1948L |
PBP 10 acetate(794466-43-6 Free base)
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PBP 10 acetate(794466-43-6 Free base) 是一种选择性甲酰肽受体 2 (FPR2) 拮抗剂。 PBP 10 acetate 选择性抑制 FPR2 介导的 NADPH 氧化酶活性,但对中性粒细胞中的 FPR1 信号传导没有影响。 PBP 10 acetate 在体外表现出 PIP2 结合活性并阻断细胞运动。 PBP 10 acetate 通过抑制病毒诱导的 ERK 激活而表现出针对流感病毒的抗病毒活性。 | |||
T75777 |
187-1, N-WASP inhibitor TFA
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187-1, N-WASP inhibitor TFA,一种14-aa 环肽及N-WASP 抑制剂,能有效阻止由磷脂酰肌醇 4,5-二磷酸酯 (PIP2) 触发的肌动蛋白装配,IC50 值达 2 μM。该化合物通过维持蛋白质自身的抑制状态,进而抑制N-WASP 激活Arp2/3 复合体。 | |||
T36938 |
PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)
PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt) |
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as the natural compound. PtdIns-(3)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (Ptd... | |||
T37030 |
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) |
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- ... | |||
T36937 |
PtdIns-(1,2-dioctanoyl) (sodium salt)
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this anal... |