Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79241 |
PHD2-IN-1
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HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
PHD2-IN-1 为一种口服活性强效 HIF-脯氨酰羟化酶2 (PHD2) 抑制剂,具有 22.53 nM 的 IC50 值,适用于贫血病研究。 | |||
T62298 |
PHD2/HDACs-IN-1
|
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PHD2/HDACs-IN-1 是一种有效的 PHD2/HDACs 混合抑制剂,能够作用于 PHD2 (IC50: 1.15 μM)、HDAC1 (IC50: 19.75 μM)、HDAC2 (IC50: 26.60 μM)、HDAC16 (IC50: 15.98 μM)。PHD2/HDACs-IN-1 是一种低毒性肾保护剂,能够用于顺铂诱导的急性肾损伤 (AKI) 的研究。 | |||
T1823 |
IOX2
IOX 2,JICL38 |
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
IOX2 (IOX 2) 是特异性的脯氨酰羟化酶-2 抑制剂,IC50=22 nM。 | |||
T79797 |
PHD-IN-1
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
PHD-IN-1(compound 80)作为PHD2的抑制剂,显示出 IC50 ≤5 nM 的高效活性。在Caco2-HIFla-HiBiT-clone-1和Hep3B细胞系中进行的EPO Elisa实验中,其EC50值均为2.5 μM。 | |||
T61458 |
HIF-PHD-IN-2
|
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HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1]. | |||
T39040 |
HIF-PHD-IN-1
|
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HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising. | |||
T68511 |
KRH102140
|
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KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH102140 decreased the mRNA levels of HIF-regulated downstream target genes associated with angiogenesis and energy metabolism such as vascular endothelial growth factor, adrenomedullin, Glut1, aldolase A, enolase 1 and monocarboxylate transporter 4. KRH102140 also inhibited tube format... |