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Cat. No.	Product Name	Target	Signaling Pathways
T9627	PHD-1-IN-1	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	PHD-1-IN-1 是口服有效的缺氧诱导因子脯氨酰羟化酶结构域 1抑制剂，IC50为 0.034 μM。它与活性位 Fe2+具有独特的单齿结合相互作用，并诱导形成一个 “Arg367-out” 口袋。
T39040	HIF-PHD-IN-1
	HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.
T79797	PHD-IN-1	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	PHD-IN-1（compound 80）作为PHD2的抑制剂，显示出 IC50 ≤5 nM 的高效活性。在Caco2-HIFla-HiBiT-clone-1和Hep3B细胞系中进行的EPO Elisa实验中，其EC50值均为2.5 μM。
T75098	HIF-PHD-IN-3	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	HIF-PHD-IN-3 是一种有效的 hiPSC-CM 心脏保护支架，对 HIF-PHD 有潜在的抑制作用，可调节血红素加氧酶-1，可用于研究贫血。
T1823	IOX2 IOX 2,JICL38	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	IOX2 (IOX 2) 是特异性的脯氨酰羟化酶-2 抑制剂，IC50=22 nM。
T61458	HIF-PHD-IN-2
	HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].
T79798	PHD-IN-2	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	PHD-IN-2（Compound 91）是一种高效的PHD拮抗剂，具有IC50值小于5 nM，能在HEP3B细胞中诱导促红细胞生成素的合成，EC50值小于2.5 μM。此化合物主要用于心血管、代谢、血液、肺部、肾脏、肝脏疾病、伤口愈合以及癌症等研究领域。
T61727	HDAC6/8/BRPF1-IN-1
	HDAC6/8/BRPF1-IN-1 is a dual inhibitor that targets HDAC6, HDAC8, and the bromodomain and PHD finger containing protein 1 (BRPF1). It exhibits inhibitory activity against HDAC1, HDAC6, and HDAC8 with IC50 values of 797 nM, 344 nM, and 908 nM, respectively. In addition, it inhibits BRPF1 with a Kd value of 175.2 nM. This compound is utilized in cancer research [1].

化合物

Cat.No: T9627

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: T39040

Cat.No: T79797

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: T75098

Target: Reactive Oxygen Species

Cat.No: T1823

Synonym: IOX 2,JICL38

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: T61458

Cat.No: T79798

Target: HIF/HIF Prolyl-Hydroxylase

HDAC6/8/BRPF1-IN-1

Cat.No: T61727

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