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Search Results for " pgds "

10

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T41267	PROTAC(H-PGDS)-7
	PROTAC(H-PGDS)-7 是一种有选择性的、有效的小分子造血前列腺素 D 合酶（H-PGDS）PROTAC 降解剂，在 KU812细胞中展现出降解活性，DC50为 17.3 pM。PROTAC(H-PGDS)-7是一种类药化合物，能有效抑制前列腺素 D2 (PGD2)的产生，抑制炎症因子重生作用。PROTAC(H-PGDS)-7是治疗 DMD 和其他H-PGDS 相关疾病的候选化合物。
T1866	AT-56	Others; PGE Synthase	Immunology/Inflammation; Others
	AT56 是口服有活性的脂钙蛋白型前列腺素 D 合酶 (L-PGDS) 选择性抑制剂，其IC50=95 μM，Ki=75 μM。它能够特异性地抑制L-PGDS 催化的 PGD2介导的嗜睡或疼痛反应。
T7948	HPGDS inhibitor 2 GSK-2894631A	PGE Synthase	Immunology/Inflammation
	HPGDS inhibitor 2 (GSK-2894631A) 是高效的造血前列腺素 D 合成酶(H-PGDS)选择性抑制剂(IC50:9.9 nM)。
T1804	HPGDS inhibitor 1 HPGDS-inhibitor-1	PGE Synthase	Immunology/Inflammation
	HPGDS inhibitor 1 是口服具有活性的HPGDS 选择性抑制剂，在酶和细胞分析中的IC50值分别为 0.6 nM 和 32 nM，但对 L-PGDS、mPGES、COX-1、COX-2 、5-LOX 无抑制作用。
T2681	hPGDS-IN-1	PGE Synthase	Immunology/Inflammation
	hPGDS-IN-1是 hPGDS 抑制剂，使用荧光偏振检测或通过 EIA 法测得的 IC50值为12 nM。
T61250	HPGDS inhibitor 3
	HPGDS inhibitor 3 is a powerful oral compound that selectively inhibits the hematopoietic prostaglandin D synthase (H-PGDS). With an IC50 value of 9.4 nM and EC50 of 42 nM, it demonstrates high potency in peripherally restricting H-PGDS. Moreover, HPGDS inhibitor 3 exhibits excellent selectivity with no associated central nervous system toxicity. This compound also possesses favorable pharmacokinetic properties in mouse, rat, and dog models. Additionally, HPGDS inhibitor 3 displays noteworthy an...
T69730	F092	PGE Synthase	Immunology/Inflammation
	F092 是一种高效的造血前列腺素 D 合成酶 (H-PGDS) 抑制剂，可以用于研究过敏性炎症和与血管相关的疾病。
T38350	TAS 205
	TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sens...
T15503	HQL-79	Others	Others
	HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 μM and IC50: 6 μM). It also shows no obvious effect on COX-1, COX-2, m-P
T38306	tetranor-PGDM
	Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PG...

化合物

PROTAC(H-PGDS)-7

Cat.No: T41267

Cat.No: T1866

Target: Others, PGE Synthase

HPGDS inhibitor 2

Cat.No: T7948

Synonym: GSK-2894631A

Target: PGE Synthase

HPGDS inhibitor 1

Cat.No: T1804

Synonym: HPGDS-inhibitor-1

Target: PGE Synthase

Cat.No: T2681

Target: PGE Synthase

HPGDS inhibitor 3

Cat.No: T61250

Cat.No: T69730

Target: PGE Synthase

Cat.No: T38350

Cat.No: T15503

Target: Others

Cat.No: T38306

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03120	Prostaglandin D2 Synthase Protein, Human, Recombinant (His) PDS,L-PGDS,PGDS,PGDS2,LPGDS	Human	HEK293 Cells
	Prostaglandin D2 Synthase Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.1 kDa and the accession number is P41222.
TMPJ-00690	PGDS Protein, Human, Recombinant Glutathione-Requiring Prostaglandin D Synthase,PGDS...	Human	E. coli
	Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macrophages, and placenta, and it exists in the form of homodimer in living body. HPGDS is a cytosolic enzyme that isomerizes PGH(2). HPGDS is a bifunctional enzyme that catalyzes both the conversion of PGH2 to PGD2 and also shows low glutathione-peroxidase activity towards cumenehydrop...
TMPY-04624	Prostaglandin D2 Synthase Protein, Mouse, Recombinant (His) Ptgs3,L-PGDS,prostaglandin D2 synthase 21kDa (brain...	Mouse	HEK293 Cells
	Prostaglandin D2 Synthase Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.9 kDa and the accession number is O09114-1.
TMPY-04077	HPGDS/PGD2 Protein, Human, Recombinant (His) hematopoietic prostaglandin D synthase,PGD2,GSTS1-1,GSTS1,	Human	E. coli
	HPGDS/PGD2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 24.2 kDa and the accession number is O60760.

重组蛋白

Prostaglandin D2 Synthase Protein, Human, Recombinant (His)

Cat.No: TMPY-03120

Species: Human

Expression System: HEK293 Cells

PGDS Protein, Human, Recombinant

Cat.No: TMPJ-00690

Species: Human

Expression System: E. coli

Prostaglandin D2 Synthase Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04624

Species: Mouse

Expression System: HEK293 Cells

HPGDS/PGD2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04077

Species: Human

Expression System: E. coli

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