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抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T4624 PGD2-IN-1

PGD2-inhibitor

Prostaglandin Receptor GPCR/G Protein; Immunology/Inflammation
PGD2-IN-1 (PGD2-inhibitor) 是 一种有效的DP 受体拮抗剂(IC50 : 0.3 nM),是一种可以抑制前列腺素D2 (PGD2)信号传导的化合物。PGD2-IN-1 专门针对和调节PGD2受体或参与PGD2合成或代谢的酶的活性。
T71088 AM-211 sodium

AM-211 sodium is a novel and potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it shows selectivity over other prostanoid receptors and enzymes. AM211 exhibits good oral bioavailability in rats and dogs and dose-dependently inhibits 13,14-dihydro-15-keto-PGD(2)-induced leukocytosis in a guinea pig pharmacodynamic assay.
T73336 Ketotifen

酮替芬,HC 20-511

Ketotifen (HC 20-511)为第二代口服活性非竞争性组胺1(H1)受体阻滞剂兼肥大细胞稳定剂,能体外阻断6-磷酸葡萄糖酸脱氢酶(6-PGD)。其对SARS-CoV-2及流感病毒(Influenza virus)展现出抗病毒活性,适用于自身免疫性脑脊髓炎(EAE)与哮喘发作预防研究。
T38389 Prostaglandin D2 Ethanolamide

Prostaglandin D2 Ethanolamide

Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of minia...

化合物

PGD2-IN-1
Cat.No: T4624
Synonym: PGD2-inhibitor
Target: Prostaglandin Receptor
AM-211 sodium
Cat.No: T71088
Synonym:
Target:
Ketotifen
Cat.No: T73336
Synonym: 酮替芬,HC 20-511
Target:
Prostaglandin D2 Ethanolamide
Cat.No: T38389
Synonym: Prostaglandin D2 Ethanolamide
Target:
Cat. No. Product Name Target Signaling Pathways
T13831 Prostaglandin D2

PGD2

Endogenous Metabolite Metabolism
Prostaglandin D2 (PGD2) (PGD2) 是哺乳动物大脑中主要产生的前列腺素之一,为最有效的内源性睡眠促进剂之一,并通过抑制炎症发挥保护作用。

天然产物

Prostaglandin D2
Cat.No: T13831
Synonym: PGD2
Target: Endogenous Metabolite
TargetMol Loading
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