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Targets Recommended: Others

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抑制剂 & 化合物

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天然产物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T12929 SKF-34288 hydrochloride

3 - 巯基吡啶甲酸,3-Mercaptopicolinic acid hydrochloride

Others Others
SKF-34288 hydrochloride (3-Mercaptopicolinic acid hydrochloride) 是一种磷酸烯醇丙酮酸羧激酶抑制剂。它抑制 Asn 代谢并导致氨基酸和酰胺的增加。它通过糖异生途径中 PEPCK 的特异性抑制来抑制葡萄糖合成,是降血糖药。

化合物

SKF-34288 hydrochloride
Cat.No: T12929
Synonym: 3 - 巯基吡啶甲酸,3-Mercaptopicolinic acid hydrochloride
Target: Others
Cat. No. Product Name Target Signaling Pathways
TN1334 7-Methoxyrosmanol

7ALPHA-甲氧基迷迭香酚,7-O-Methylrosmanol

cAMP GPCR/G Protein
7-Methoxyrosmanol (7-O-Methylrosmanol) 是一种酚类二萜,从迷迭香中分离得到,可抑制 PEPCK 和 G6Pase 启动子的 cAMP 反应。

天然产物

7-Methoxyrosmanol
Cat.No: TN1334
Synonym: 7ALPHA-甲氧基迷迭香酚,7-O-Methylrosmanol
Target: cAMP
Cat. No. Product Name Species Expression System
TMPY-04764 PCK2 Protein, Human, Recombinant (His & GST)

PEPCK-M,PEPCK2,PEPCK,phosphoenolp...

Human Baculovirus Insect Cells
PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. PCK2 is a potential therapeutic target for aggressive prostate tumors.
TMPJ-00955 MDH1 Protein, Human, Recombinant (His)

Cytosolic Malate Dehydrogenase,MDH1,MDHA,Diiodophenylpyruvat...

Human E. coli
Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted up...

重组蛋白

PCK2 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04764
Species: Human
Expression System: Baculovirus Insect Cells
MDH1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00955
Species: Human
Expression System: E. coli
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