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Search Results for " pdi "

15

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24608	PDI-IN-P1 PDI inhibitor P1,PDIINP1,PDI-inhibitor-P1
	PDI-IN-P1 is an inhibitor of protein disulfide isomerase.
T8640	G6PDi-1	Dehydrogenase	Metabolism
	G6PDi-1 是一种有效的 G6PD 抑制剂。它消耗 NADPH 并减少炎性细胞因子的产生。
T25821	ML359 ML-359,ML 359	Others	Others
	ML359 是选择性可逆的蛋白质二硫键异构酶有效抑制剂(IC50:250 nM)。它对体内血栓形成具有抑制作用。
T6800	CCF642 AC1LYELL	Others	Others
	CCF642 (AC1LYELL) 是蛋白质二硫键异构酶抑制剂(IC50:2.9 μM)。它在多发性骨髓瘤细胞中引起急性内质网应激，并伴随凋亡诱导的钙释放，表现出广泛的抗多发性骨髓瘤作用。
T30473	Bis-hema ipdi
	Bis-hema ipdi is a bioactive chemical.
T5453	3-Methyltoxoflavin 3-methyl toxoflavin	Others	Others
	3-Methyltoxoflavin (3-methyl toxoflavin) 是蛋白质二硫键异构酶抑制剂(IC50:170 nM)。
T5534	LOC14	Others	Others
	LOC14 是一种蛋白质二硫键异构酶抑制剂 (EC50=500 nM;Kd=62 nM)。它抑制 PDIA3 活性，降低肺上皮细胞中 HA 的分子内二硫键和随后的寡聚化。它在小鼠肝微粒体和血浆中表现出高稳定性，低内在微粒体清除率和低血浆蛋白结合。
T11141	E64FC26	Others	Others
	E64FC26 是一种有效的蛋白质二硫键异构酶 (PDI) 家族泛抑制剂，具有抗肿瘤活性，抑制 PDIA1、PDIA3、PDIA4、TXNDC5 和 PDIA6，可用于研究多发性骨髓瘤和胰腺癌。
T41277	PACMA 31	Others	Others
	PACMA 31 是一种不可逆的共价蛋白二硫键异构酶 (PDI) 抑制剂，IC50 为 10 μM。 PACMA 31 显着抑制卵巢肿瘤生长并表现出肿瘤靶向能力。
T69718	Bacitracin F
	Bacitracin F is a major Bacitracin analog -- a peptide antibiotic used as an inhibitor of protein disulfide isomerase (PDI).
T19505	PBDB-T	Others	Others
	PBDB-T serves as a wide-bandgap polymer donor within polymer solar cells that utilize Perylene Diimide (PDI) as the base.
T35608	16F16
	16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal ...
T69700	BAP2
	BAP2 is a novel inhibitor of protein disulfide isomerase (PDI).
T71589	AS15
	AS15 is a novel covalent nanomolar inhibitor of protein disulfide isomerase (PDI).
T39812	(E/Z)-E64FC26 (E/Z)-E64FC26
	(E/Z)-E64FC26 is a mixture complex comprising E-E64FC26 and Z-E64FC26. E-E64FC26 is a highly potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50 values of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. Furthermore, E64FC26 demonstrates anti-myeloma activity.

化合物

Cat.No: T24608

Synonym: PDI inhibitor P1,PDIINP1,PDI-inhibitor-P1

Cat.No: T8640

Target: Dehydrogenase

Cat.No: T25821

Synonym: ML-359,ML 359

Target: Others

Cat.No: T6800

Synonym: AC1LYELL

Target: Others

Cat.No: T30473

3-Methyltoxoflavin

Cat.No: T5453

Synonym: 3-methyl toxoflavin

Target: Others

Cat.No: T5534

Target: Others

Cat.No: T11141

Target: Others

Cat.No: T41277

Target: Others

Cat.No: T69718

Cat.No: T19505

Target: Others

Cat.No: T35608

Cat.No: T69700

Cat.No: T71589

Cat.No: T39812

Synonym: (E/Z)-E64FC26

Cat. No.	Product Name	Target	Signaling Pathways
T4S1057	Tripdiolide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.
T3752	4-Hydroxybenzyl alcohol 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	4-Hydroxybenzyl alcohol (P-Methylolphenol) 是广泛分布于各种植物中的一种酚类天然产物，具有抗炎、抗氧化和抗伤害感受活性。它抑制肿瘤血管生成和生长，有神经保护作用。
T82003	Juniferdin
	Juniferdin是一种抑制Protein disulfide isomerase (PDI)，IC50为3.5 μM，旨在阻断HIV传播的化合物。此外，Juniferdin展现出细胞毒性并能抑制血小板聚集。
T74207	Ribostamycin
	Ribostamycin (Vistamycin) 是一种广谱氨基糖苷类抗生素 (antibiotic)。Ribostamycin 对革兰氏阴性和革兰氏阳性细菌感染有效。Ribostamycin 还抑制PDI 的伴侣活性。

天然产物

Cat.No: T4S1057

Target: IL Receptor, TNF

4-Hydroxybenzyl alcohol

Cat.No: T3752

Synonym: 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇

Target: Apoptosis, Endogenous Metabolite

Cat.No: T82003

Cat.No: T74207

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