Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6189 |
Mirdametinib
PD325901,PD0325901 |
Apoptosis; MEK; Autophagy | Apoptosis; Autophagy; MAPK |
Mirdametinib (PD325901) 是一种 MEK 抑制剂 (IC50=0.33 nM),具有选择性、非 ATP 竞争性和口服活性。Mirdametinib 具有抗肿瘤活性,可以抑制 p-ERK1/2 的表达并诱导细胞凋亡。 | |||
T40217 |
PD0325901-O-C2-dioxolane
PD0325901-O-C2-dioxolane |
||
PD0325901-O-C2-dioxolane is a chemical compound primarily composed of the MEK inhibitor PD0325901. It can be utilized, in conjunction with either a VHL or CRBN E3 ligase ligand, for the synthesis of MEK1/2 degrader. | |||
T13782 |
MS432
|
MEK | MAPK |
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2. | |||
T18668 |
(S,R,S)-AHPC-Me-C10-Br
|
Others | Others |
(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate that functions as a ligand-linker for E3 ligases. This compound incorporates a VHL E3 ligase linker and MS432, derived from the MEK1/2 inhibitor PD0325901[1]. |