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Search Results for " pbt "

Targets Recommended: Others

7

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9159	PBT-1033 PB 1033,PBT1033,PBT-2,PBT 2,PBT2	Others	Others
	PBT-1033 (PBT-2) 是一种潜在的神经保护剂，用于治疗阿尔茨海默病和亨廷顿病。
T33895	PBT-1033 hydrochloride PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033
	PBT-1033 hydrochloride is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
T25501	HI-236 HI 236,D-PBT,D PBT,DPBT
	HI-236 is used as a non-nucleoside HIV-1 reverse-transcriptase inhibitor.
T71172	U 80215
	U 80215 is an enzyme-competitive inhibitor.
T71174	PBT434 HBr
	PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is g...
T72280	PBT434 methanesulfonate
	PBT434 methanesulfonate 为一种有效、口服活性并能穿透血脑屏障的α-synuclein aggregation抑制剂，同时担任铁螯合剂和跨细胞铁运输的调节剂。该化合物抑制铁介导的氧化还原活性及α-synuclein聚集，可有效防止SNpc神经元丢失，显示出在PD研究中的应用潜力。
T39286	Br-PBTC
	Br-PBTC is a highly potent, 2/4 subtype-selective positive allosteric modulator of nicotinic acetylcholine receptors (nAChRs). It specifically targets α2β2, α2β4, α4β2, α4β4, (α4β2)2α4, and (α4β2)2β2 subtypes of nAChRs, with EC50 values ranging from 0.1 to 0.6 μM. Br-PBTC exerts its activity by binding to the c-tail region of an α subunit.

化合物

Cat.No: T9159

Synonym: PB 1033,PBT1033,PBT-2,PBT 2,PBT2

Target: Others

PBT-1033 hydrochloride

Cat.No: T33895

Synonym: PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033

Cat.No: T25501

Synonym: HI 236,D-PBT,D PBT,DPBT

Cat.No: T71172

Cat.No: T71174

PBT434 methanesulfonate

Cat.No: T72280

Cat.No: T39286

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01935	c-Kit Protein, Human, Recombinant (His) PBT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma vi...	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
TMPY-04051	c-Kit Protein, Human, Recombinant (hFc) SCFR,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene h...	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is P10721-2.
TMPK-01270	CD117 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) KIT,PBT,c-kit,CD117,SCFR,ckit	Cynomolgus,Rhesus	HEK293 Cells
	The c-kit proto-oncogen (CD117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and megakaryocytic cell lineages.
TMPK-00777	CD117 Protein, Mouse, Recombinant (His) ckit,PBT,SCFR,KIT,CD117,c-kit	Mouse	HEK293 Cells
	The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and megakaryocytic cell lineages. CD117 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 56.63 kDa and the accession number is P05...
TMPK-00805	CD117 Protein, Human, Recombinant (His & Avi), Biotinylated CD117,EC 2.7.10,EC 2.7.10.1,c-kit,KIT,SCFR,PBT,ckit	Human	HEK293 Cells
	The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and megakaryocytic cell lineages. CD117 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 58.60 kDa and the...
TMPY-06656	c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated CD117,SCFR,C-Kit,v-kit Hardy-Zuckerman 4 feline sarcoma vira...	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 58.50 kDa and the accession number is P10721-2.
TMPY-03567	c-Kit Protein, Human, Recombinant (aa 50-190, His) SCFR,PBT,C-Kit,CD117,v-kit Hardy-Zuckerman 4 feline...	Human	E. coli
	c-Kit Protein, Human, Recombinant (aa 50-190, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.9 kDa and the accession number is P10721-1.
TMPY-04564	c-Kit Protein, Human, Recombinant (aa 540-972, His & GST) C-Kit,PBT,SCFR,CD117,v-kit Hardy-Zuckerman 4 feline...	Human	Baculovirus Insect Cells
	c-Kit Protein, Human, Recombinant (aa 540-972, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P10721-2.
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc) KIT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog...	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti...

重组蛋白

c-Kit Protein, Human, Recombinant (His)

Cat.No: TMPY-01935

Species: Human

Expression System: HEK293 Cells

c-Kit Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04051

Species: Human

Expression System: HEK293 Cells

CD117 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-01270

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD117 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00777

Species: Mouse

Expression System: HEK293 Cells

CD117 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00805

Species: Human

Expression System: HEK293 Cells

c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06656

Species: Human

Expression System: HEK293 Cells

c-Kit Protein, Human, Recombinant (aa 50-190, His)

Cat.No: TMPY-03567

Species: Human

Expression System: E. coli

c-Kit Protein, Human, Recombinant (aa 540-972, His & GST)

Cat.No: TMPY-04564

Species: Human

Expression System: Baculovirus Insect Cells

CD117 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00402

Species: Human

Expression System: HEK293 Cells

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