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3

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24988	7ETMC 7 ETMC,7-ETMC
	7ETMC is a selective Human Cytochrome P450s 1A1 and 1A2 inhibitor. 7ETMC showed IC50s of 0.46 μM and 0.50 μM for P450s 1A1 and 1A2 in the first six minutes, respectively, and did not show any inhibition activity for P450s 2A6 and 2B1 even at the dose of 5
T37926	7-Ethoxy-4-(trifluoromethyl)coumarin
	7-Ethoxy-5-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs).1Upon O-deethylation by CYPs, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP activity. HFC displays excitation/emission maxima of 410/510 nm, respectively. 1.Buters, J.T.M., Schiller, C.D., and Chou, R.C.A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation o...
T35712	Debutyldronedarone hydrochloride SR35021 hydrochloride
	N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...

化合物

Cat.No: T24988

Synonym: 7 ETMC,7-ETMC

7-Ethoxy-4-(trifluoromethyl)coumarin

Cat.No: T37926

Debutyldronedarone hydrochloride

Cat.No: T35712

Synonym: SR35021 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
TN6848	Piperonylic acid 胡椒酸,2H-1,3-benzodioxole-5-carboxylic acid	P450	Metabolism
	Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) 是一种具有亚甲二氧基活性的天然分子，与反式肉桂酸结构相似，可作为选择性反式肉桂酸 4-羟化酶的灭活剂。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN3627	Chalepensin	ATPase; NADPH-oxidase; P450; Antifection	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential drug interaction through mechanism-based inhibition. Chalepensin shows antiprotozoal activity; it also can cause significant inhibition of radicle growth of A. hypochondriacus and E. crus-galli.

天然产物

Piperonylic acid

Cat.No: TN6848

Synonym: 胡椒酸,2H-1,3-benzodioxole-5-carboxylic acid

Target: P450

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Cat.No: TN3627

Target: ATPase, NADPH-oxidase, P450, Antifection

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