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Search Results for " p 19 "

13

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1819L	Substance P 1-9 aceate	Neurotensin Receptor	GPCR/G Protein
	Substance P 1-9 aceate 是九肽，可减少豚鼠回肠和膀胱对 P 物质的失活。
TP1819	Substance P (1-9)
	Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder. Subtance P is responsible for a number of excitatory effects on both central and peripheral neurons.
T63122	CBP/p300-IN-19	Others	Others
	CBP/p300-IN-19 是一种 p300/CBP HAT 的有效抑制剂，能够作用于 p300-HAT (IC50: 1.4 μM)、CBP-HAT (IC50: 2.2 μM)、PCAF (IC50>100 μM)、Myst3 (IC50>100 μM)。CBP/p300-IN-19 具有抗肿瘤活性。
T63565	CBP/p300-IN-19 hydrochloride	Others	Others
	CBP/p300-IN-19 hydrochloride 是选择性的、有效的 p300/CBP HAT 抑制剂，能够作用于 p300-HAT (IC50: 1.4 μM)、CBP-HAT (IC50: 2.2 μM)、PCAF (IC50>100 μM)、Myst3 (IC50>100 μM)。CBP/p300-IN-19 hydrochloride 具有抗肿瘤作用。
T8533	ML318	Others; Antibiotic	Microbiology/Virology; Others
	ML318 是 PvdQ 酰基转移酶的联芳基腈抑制剂，可以结合在酰基结合位点上，IC50为 20 nM。它抑制铜绿假单胞菌的 IC50为 19 μM。它可防止嘧啶的产生并限制了铜绿假单胞菌在铁限制条件下的生长。
T80285	KAMP-19
	KAMP-19，一款角蛋白衍生的抗菌肽，展示出对铜绿假单胞菌 (P. aeruginosa) 的有效抗菌作用。
T63267	P-gp/BCRP-IN-1	Others	Others
	P-gp/BCRP-IN-1 (compound 19) 是一种潜在的、相对安全的、口服有效的外排转运蛋白(P-gp 和 BCRP) 抑制剂。P-gp/BCRP-IN-1 通过抑制 P-gp 和BCRP 的外排功能产生耐药性逆转，P-gp/BCRP-IN-1可克服紫杉醇的耐药性，提高紫杉醇的口服生物利用度。
T75067	Antimalarial agent 19	Parasite	Microbiology/Virology
	Antimalarial agent 19（compound 6e）是一种活性抗疟疾化合物，对K1型恶性疟原虫和伯氏疟原虫展现出较强的抑制效果，其EC50值分别为0.3 µM和15.3 µM。相较于γ-肝硫平，该化合物具有更好的水溶性、肠道渗透性以及微粒体稳定性。
T62737	KRAS inhibitor-15	Others	Others
	KRAS inhibitor-15 (compound 3-19) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.954 μM)。KRAS inhibitor-15 在 MIA PaCA-2，A549 细胞中表现出 p-ERK 抑制作用，IC50s 分别为 2.03，>33.3 μM。KRAS inhibitor-15 具有潜力进行胰腺癌、结直肠癌和肺癌的研究。
T38276	Benzomalvin C	Others	Others
	Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
T61643	Vonoprazan hydrochloride	Others	Others
	Vonoprazan hydrochloride 是一种高效且具口服活性的质子泵抑制剂 (PPI) 和钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB)，展示出优秀的抗分泌活性。在 pH 为 6.5 的条件下，该化合物可抑制猪胃微粒体内 H+,K+-ATPase 的酶活性，呈现出 19 nM 的 IC50 值。Vonoprazan hydrochloride 主要应用于胃酸相关疾病的研究，包括胃食管反流病和消化性溃疡，并可用于根除幽门螺杆菌。
TP1052	Protein Kinase C (19-31) (TFA)(121545-65-1,free) PKC (19-31) (TFA),Protein Kinase C (19-31) (TFA)
	Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate p
T36666	Dehydro Warfarin	Others	Others
	Dehydro warfarin is a metabolite of (±)-warfarin .1It is formed from (±)-warfarin by rat liver microsomes. 1.Kaminsky, L.S., Fasco, M.J., and Guengerich, F.P.Comparison of different forms of liver, kidney, and lung microsomal cytochrome P-450 by immunological inhibition of regio- and stereoselective metabolism of warfarinJ. Biol. Chem.254(19)9657-9662(1979)

化合物

Substance P 1-9 aceate

Cat.No: TP1819L

Target: Neurotensin Receptor

Substance P (1-9)

Cat.No: TP1819

Cat.No: T63122

Target: Others

CBP/p300-IN-19 hydrochloride

Cat.No: T63565

Target: Others

Cat.No: T8533

Target: Others, Antibiotic

Cat.No: T80285

Cat.No: T63267

Target: Others

Antimalarial agent 19

Cat.No: T75067

Target: Parasite

KRAS inhibitor-15

Cat.No: T62737

Target: Others

Cat.No: T38276

Target: Others

Vonoprazan hydrochloride

Cat.No: T61643

Target: Others

Protein Kinase C (19-31) (TFA)(121545-65-1,free)

Cat.No: TP1052

Synonym: PKC (19-31) (TFA),Protein Kinase C (19-31) (TFA)

Dehydro Warfarin

Cat.No: T36666

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN3283	8alpha-Hydroxylabda-13(16),14-dien-19-yl p-hydroxycinnamate	Others	Others
	8alpha-Hydroxylabda-13(16),14-dien-19-yl p-hydroxycinnamate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3283，CAS号为 117254-98-5。
TN6287	Apigenin 7-O-(2'',6''-di-O-E-p-coumaroyl)glucoside Anisofolin B
	Apigenin 7-O-(2'',6''-di-O-E-p-coumaroyl)glucoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6287，CAS号为 1448779-19-8。
T38262	Sphingosine (d14:1)	Others	Others
	Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively).

天然产物

8alpha-Hydroxylabda-13(16),14-dien-19-yl p-hydroxycinnamate

Cat.No: TN3283

Target: Others

Apigenin 7-O-(2'',6''-di-O-E-p-coumaroyl)glucoside

Cat.No: TN6287

Synonym: Anisofolin B

Sphingosine (d14:1)

Cat.No: T38262

Target: Others

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