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Cat. No.	Product Name	Target	Signaling Pathways
T21588	Olomoucine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂，IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。
T35696	Olomoucine II
	Olomoucine II is an inhibitor of cyclin-dependent kinases (CDKs; IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 μM for Cdk1, -2, -4, -7, and -9, respectively).1It is selective for CDKs over 10 additional kinases (IC50s = >100 μM for all) but does inhibit ERK2 (IC50= 32 μM) and the ATP-binding cassette transporter B1 (ABCB1; IC50= 6.4 μM).1,2Olomoucine II inhibits proliferation of a variety of cancer cells, including those expressing wild-type p53 or mutant p53 (mean IC50s = 7.4 and 10.1 μM, respectively...
T23589	9-Isopropylolomoucine 9 Isopropylolomoucine,N9 Isopropylolomoucine,N9Isopropylolomoucine,N9-Isopropylolomoucine	CDK	Cell Cycle/Checkpoint
	9-Isopropylolomoucine (N9-Isopropylolomoucine) 是一种细胞周期蛋白依赖性激酶抑制剂，是一种硫嘌呤。
T36349	CGP 74514 dihydrochloride
	Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002. Yu et al (2013) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res. 63 1822 PMID:12702569 \|Furet et al (2000) Structure-based design of potent CDK1 inhibitors derived from olomoucine. J.Comput.Aided Mol.Des. 14 40...
T70988	Ibulocydine
	Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc...

化合物

Cat.No: T21588

Target: ERK, CDK

Olomoucine II

Cat.No: T35696

9-Isopropylolomoucine

Cat.No: T23589

Synonym: 9 Isopropylolomoucine,N9 Isopropylolomoucine,N9Isopropylolomoucine,N9-Isopropylolomoucine

Target: CDK

CGP 74514 dihydrochloride

Cat.No: T36349

Cat.No: T70988

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