Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6916 |
OICR-9429
OICR 9429 |
Histone Methyltransferase; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
OICR-9429 是一个新颖的相互作用的小分子Wdr5-MLL 拮抗剂,IC50是 5 uM,在体外抑制急性髓性白血病细胞。 | |||
T39978 |
Dimethyl-F-OICR-9429-COOH
|
||
Dimethyl-F-OICR-9429-COOH, a ligand for WD40 repeat domain protein 5 (WDR5). This compound is utilized as a key component in the synthesis of PROTACs. | |||
T39977 |
OICR-9429-N-C2-NH2
OICR-9429-N-C2-NH2 |
||
OICR-9429-N-C2-NH2, a ligand for WDR5, intermediate 2, serves as a crucial compound in the synthesis of PROTACs. | |||
T77495 |
WDR5-IN-6
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
WDR5-IN-6 是一种 WDR5 抑制剂,靶向 WBM 位点。WDR5-IN-6 与靶向 WIN 位点的 WDR5 抑制剂 OICR-9429 具有高度协同作用。WDR5-IN-6 具有较强的抗肿瘤活性,可抑制神经母细胞瘤细胞系的细胞增殖。WDR5-IN-6 可用于神经母细胞瘤的研究。 | |||
T12290 |
OICR-0547
|
Others | Others |
OICR-0547 is a closely related derivative of OICR-9429. OICR-9429 is a novel small-molecule Wdr5-MLL interaction antagonist. |