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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6875	Lesinurad RDEA594,雷西那德,来司诺雷	OAT	Membrane transporter/Ion channel
	Lesinurad (RDEA594) 是URAT1和OAT 抑制剂。Lesinurad 用作肾转运蛋白OAT1 和OAT3 的底物，Km 分别为 0.85 和 2 μM。
T6098	Cabotegravir GSK744,GSK-1265744,卡博特韦,S/GSK1265744	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cabotegravir (S/GSK1265744) 是一种HIV 整合酶抑制剂，可研究艾滋病。它抑制OAT1 和OAT3，IC50值为 0.81 和0.41 μM。
T69889	JBP485
	JBP485 is an inhibitor of renal transporters OAT1 and OAT3. JBP485 is an antihepatitis agent as a substrate for intestinal PEPT1.
T62432	KPH2f
	KPH2f 是一种安全、口服有效的 URAT1/GLUT9双抑制剂，对 URAT1和 GLUT9 的 IC50分别为 0.24 μM 和 9.37 μM。KPH2f 对 OAT1 和 ABCG2 几乎没有影响 (IC50分别为 32.14 和 26.74 μM)。
T27275	Epaminurad
	Epaminurad (UR-1102) 是一种口服有效的和选择性的URAT1(尿酸转运体 1) 抑制剂，其Ki 为 0.057 μM。Epaminurad 适度地抑制OAT1和OAT3(有机阴离子转运体)。Epaminurad 是一种促尿酸排泄剂。Epaminurad 可用于痛风和高尿酸血症的研究。
T35721	4’-hydroxy Trazodone
	4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is selective for OAT3 over OAT1 (Ki= >200 μM).2 1.Yamato, C., Takahashi, T., Fujita, T., et al.Studies on metabolism of trazodone, II. Metabolic fate after intravenous administration and effects on liver microsomal drug-metabolizing enzymes in ratsXenobiotica4(12)765-777(1974) 2.Zou, L., Matsson, P., Stecula, A., et al.Drug metabolites poten...
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...
T21301	Lesinurad sodium Lesinurad,RDEA 594,RDEA-594,RDEA594
	UNC569, the first small-molecule MER inhibitor, inhibits Mer activation and downstream signaling through ERK1/2 and AKTwith. UNC569 shows efficacy against acute lymphoblastic leukemia in vitro and in vivo.

化合物

Lesinurad

Cat.No: T6875

Synonym: RDEA594,雷西那德,来司诺雷

Target: OAT

Cabotegravir

Cat.No: T6098

Synonym: GSK744,GSK-1265744,卡博特韦,S/GSK1265744

Target: HIV Protease

Indoxyl Sulfate-d5 potassium salt

Synonym: Lesinurad,RDEA 594,RDEA-594,RDEA594

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T81629	OAT1/3-IN-2
	OAT1/3-IN-2（化合物8）是一种针对OAT1和OAT3的双重抑制剂。该化合物能够以10 μM的浓度逆转Cys-Hg对HEK-OAT1细胞的毒害作用，并可能对肾脏具有保护效应。OAT1/3-IN-2适用于研究汞导致的肾脏损伤。
T81630	OAT1/3-IN-1
	OAT1/3-IN-1（化合物7）是针对OAT1和OAT3的双重抑制剂。该化合物能逆转Cys-Hg（10 μM）对HEK-OAT1细胞引起的毒害，表明其对肾脏有潜在的保护效应。OAT1/3-IN-1适合用于探究汞引起的肾脏损伤机制研究。
T19866	Indican NSC-87517,3-Indoxyl-beta-D-glucopyranoside,3-吲哚基-beta-D-吡喃葡萄糖苷,NSC 87517,NSC87517,Indoxyl-β-D-glucoside	OAT; MRP	Immunology/Inflammation; Membrane transporter/Ion channel
	Indican (Indoxyl-β-D-glucoside) 是吲哚酚的一种糖苷，染料靛蓝和靛玉红的前体。它的主要代谢物是硫酸吲哚酚 (IS)。其中 IS 是尿毒症毒素，是有机阴离子转运蛋白1 (OAT 1)、OAT 3 和多药耐药相关蛋白4 (MRP 4) 的底物/抑制剂。