Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39785L |
TH5427
|
NUDIX hydrolase | Metabolism |
TH5427 在 NUDT5 活性和 ADP-核糖代谢中有研究的价值。它阻断孕激素依赖性、PAR 衍生的核 ATP 合成以及随后的乳腺癌细胞染色质重塑、基因调控和增殖。NUDT5是乳腺癌细胞激素依赖性基因调控和增殖的变阻器。 | |||
T2069 |
TH287
TH287 hydrochloride |
DNA/RNA Synthesis; MTH1 | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
TH287 是一种选择性的MTH1抑制剂,对 MTH1 具有高度选择性,可用于治疗癌症的研究。 | |||
T39785 |
TH5427 hydrochloride
|
||
TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation. |