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Cat. No.	Product Name	Target	Signaling Pathways
T7549	Talnetant SB 223412	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Talnetant (SB 223412) 是一种选择性、竞争性、脑渗透性 NK3 受体拮抗剂，Ki 为1.4 nM。它比对hNK-2受体的抑制性高100倍，具有调节中脑边缘和中脑皮质多巴胺能神经传递的能力。
T7633	Senktide	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Senktide 是速激肽NK3受体激动剂。
TP1851L	Scyliorhinin II acetate	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Scyliorhinin II acetate 是大鼠大脑皮层神经激肽 3 (NK3) 受体 (Ki = 2.5 nM) 的选择性激动剂。
T16114	Pavinetant AZD4901,MLE-4901,AZD2624	MEK	MAPK
	Pavinetant 是一种小分子具有口服活性的和选择性的神经激肽-3 (NK3)受体拮抗剂，可用于治疗潮热和多囊卵巢综合征(PCOS)，是治疗精神分裂症的潜在化合物。
TP1899L1	Hemokinin 1 (human) acetate(491851-53-7 free base)	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Hemokinin 1 (human) acetate(491851-53-7 free base) 是一种内源性 P 物质同系物，是速激肽 NK1 受体的选择性激动剂（NK1、NK3 和 NK2 受体的 IC50 值分别为 1.8、370 和 480 nM）。在体外对 B 细胞具有增殖和抗凋亡作用，在体内具有抗高血压作用。
T68623	RO4583298
	RO4583298 is a highly potent dual NK1/NK3 receptor antagonist with in vivo activity.
T23395	SSR 146977 hydrochloride	Others	Others
	NK3 receptor antagonist
T32004	GSK172981 GSK 172981,GSK-172981
	GSK172981 is a non-peptide tachykinin NK3 receptor antagonist with a high affinity for the recombinant human (PK (I) value 7.7) and native guinea pig (PK (I) value 7.8) tachykinin NK3 receptor. In vitro, the functional evaluation showed that GSK172981 was
TP1851	Scyliorhinin II
	Scyliorhinin II, a cyclic Tachykinin peptide, is a potent NK3 receptor agonist.
T16408	Osanetant SR142801	Others	Others
	Osanetant produces anxiolytic- and antidepressant-like effects. Osanetant is a selective NK3 receptor antagonist. It is researched for schizophrenia.
T7633L	Senktide acetate Senktide acetate(106128-89-6 free base)	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Senktide acetate 是一种选择性速激肽 NK3 受体激动剂，促进 ELM 的巩固或表达，可用于研究阿尔茨海默症。
T74413	(S)-Osanetant
	(S)-Osanetant 是 Osanetant 的S 对映体。Osanetant (SR142801) 是一种选择性的NK3受体拮抗剂。Osanetant 有抗焦虑和抗抑郁的作用，并被研究用于精神分裂症。
T75881	GR 64349 TFA
	GR 64349为一种有效且高度选择性的神经激肽 2(NK2)受体肽类拮抗剂，具有在大鼠结肠中的EC50值仅为3.7 nM。相较于NK1和NK3受体，GR 64349展现出超过1000倍与300倍的选择性差异。
TP2023	GR 64349
	Potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.
T10892	CS-003 Free base	Neurokinin receptor	GPCR/G Protein; Neuroscience
	CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on
T78104	Fosnetupitant chloride monohydrochloride Pronetupitant chloride monohydrochloride	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Fosnetupitant chloride monohydrochloride（Pronetupitant chloride monohydrochloride）为NK1受体拮抗剂，对人NK1受体和NK3受体的pKi分别为9.5和6.1。它是奈妥匹坦的亚甲基磷酸酯前体。
TP1899	Hemokinin 1, human Hemokinin 1 (human)
	Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihyperte
T62199	Talnetant hydrochloride
	Talnetant (SB 223412) hydrochloride 是一种选择性的 NK3 受体拮抗剂，能够作用于 hNK-3-CHO 细胞中 (Ki: 1.4 nM)。Talnetant hydrochloride 对 hNK-3 受体的选择性是 hNK-2 受体的 100 倍，同时在 100 μM 的浓度下对 hNK-1 也没有亲和力。
T75840	Hemokinin 1, human TFA
	Hemokinin 1, human TFA 是选择性的速激肽神经激肽 1 (NK1) 受体完全激动剂。Hemokinin 1, human TFA 也是 NK2和 NK3受体的完全激动剂。Hemokinin 1, human TFA 可以产生非阿片样物质的缓解疼痛作用。
T75880	GR 94800 TFA
	GR 94800 TFA 是有效的、选择性的神经激肽 2(NK2)受体的肽类拮抗剂，其对 NK2、NK1和 NK3受体的 pKB 值分别为 9.6、6.4 和 6.0。
T70456	Nolpitantium Free Base
	Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans. In vitro, it was a potent antagonist in functional assays for NK1 receptors such as [Sar9, Met(O2)11]substance P-induced endothelium-dependent relaxation of rabbit pulmonary artery and contraction of guinea-pig ileum. Up to 1 mkM, Nolpitantium had no eff...

化合物

Cat.No: T7549

Synonym: SB 223412

Target: Neurokinin receptor

Cat.No: T7633

Target: Neurokinin receptor

Scyliorhinin II acetate

Cat.No: TP1851L

Target: Neurokinin receptor

Cat.No: T16114

Synonym: AZD4901,MLE-4901,AZD2624

Target: MEK

Hemokinin 1 (human) acetate(491851-53-7 free base)

Cat.No: TP1899L1

Target: Neurokinin receptor

Cat.No: T68623

SSR 146977 hydrochloride

Cat.No: T23395

Target: Others

Cat.No: T32004

Synonym: GSK 172981,GSK-172981

Scyliorhinin II

Cat.No: TP1851

Cat.No: T16408

Synonym: SR142801

Target: Others

Senktide acetate

Cat.No: T7633L

Synonym: Senktide acetate(106128-89-6 free base)

Target: Neurokinin receptor

Cat.No: T74413

Cat.No: T75881

Cat.No: TP2023

CS-003 Free base

Cat.No: T10892

Target: Neurokinin receptor

Fosnetupitant chloride monohydrochloride

Cat.No: T78104

Synonym: Pronetupitant chloride monohydrochloride

Target: Neurokinin receptor

Hemokinin 1, human

Cat.No: TP1899

Synonym: Hemokinin 1 (human)

Talnetant hydrochloride

Cat.No: T62199

Hemokinin 1, human TFA

Cat.No: T75840

Cat.No: T75880

Nolpitantium Free Base

Cat.No: T70456

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