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Cat. No. Product Name Target Signaling Pathways
T21312 Afatinib

阿法替尼,Afatinib free base,BIBW 2992

EGFR; Autophagy Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Afatinib (BIBW 2992) 是一种不可逆的 EGFR 家族抑制剂,抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T1773 Afatinib Dimaleate

马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate

EGFR; HER; Autophagy Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Afatinib Dimaleate (BIBW 2992MA2) 是一种可口服的苯胺基-喹唑啉衍生物和受体酪氨酸激酶表皮生长因子受体家族的抑制剂,具有抗肿瘤活性。它抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T10849 CMLD012612

Others Others
CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).
T10848 CMLD012073

Others Others
CMLD012073 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits NIH/3T3 cells (IC50: 10 nM). CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).
T36821 FQI 1

FQI 1 是一种 SV40 因子 (LSF) 抑制剂。FQI 1 抑制细胞增殖,对 NIH/3T3、HeLa、A549 细胞的 IC50s 分别为 3、0.79、6.3 μM。FQI1 可用于癌症研究。
T36542 Prostaglandin A2

Medullin

PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]

化合物

Afatinib
Cat.No: T21312
Synonym: 阿法替尼,Afatinib free base,BIBW 2992
Target: EGFR, Autophagy
Afatinib Dimaleate
Cat.No: T1773
Synonym: 马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate
Target: EGFR, HER, Autophagy
CMLD012612
Cat.No: T10849
Synonym:
Target: Others
CMLD012073
Cat.No: T10848
Synonym:
Target: Others
FQI 1
Cat.No: T36821
Synonym:
Target:
Prostaglandin A2
Cat.No: T36542
Synonym: Medullin
Target:
TargetMol Loading
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