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36

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40548	NH-3	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	NH-3是一种高效的口服活性甲状腺激素受体（THR）拮抗剂，具有可逆行为，其IC 50为55 nM。NH-3源自选择性甲状腺激素模拟物GC-1，有效地抑制甲状腺激素与相应受体的结合，从而阻碍辅因子的招募。
T16302	NH-bis(PEG3-azide)	Others	Others
	NH-bis(PEG3-azide) 是一种属于 PEG 类的 PROTAC 连接体，可用于合成 PROTAC 分子。
T17722	Cbz-NH-PEG3-CH2COOH 苯甲氧羰酰基二聚乙二醇羧乙基	Others; PROTAC Linker	Others; PROTAC
	Cbz-NH-PEG3-CH2COOH 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T14741	Boc-NH-PEG3-CH2COOH 5,8,11-三氧杂-2-氮杂十三烷二酸 1-叔丁酯	PROTAC Linker	PROTAC
	Boc-NH-PEG3-CH2COOH 是基于 PEG 的 PROTAC linker，用于合成 PROTAC。
T17677	Boc-NH-PEG3-NHS ester 氨基叔丁酯-三聚乙二醇-NHS 酯	Others; PROTAC Linker	Others; PROTAC
	Boc-NH-PEG3-NHS ester 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T9401	Thalidomide-NH-PEG1-NH2 hydrochloride 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成。
T40016	Thalidomide-NH-CH2-COOH 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine	Ligand for E3 Ligase	PROTAC
	Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T7701	Boc-NH-PEG3 PROTAC Linker 10,2-[2-(2-T-BOC-氨基乙氧基)乙氧基]乙醇	Others; PROTAC Linker	Others; PROTAC
	Boc-NH-PEG3 (PROTAC Linker 10) 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 的合成分子。
T9382	Thalidomide-NH-C2-PEG3-OH H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是 E3 连接酶配体-linker 偶联物，可用于合成 PROTAC BCL-XL 降解剂 XZ739。
T16305	NH-bis-PEG3	Others	Others
	NH-bis-PEG3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16304	NH-bis(PEG3-C2-NH-Boc)	Others	Others
	NH-bis(PEG3-C2-NH-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14742	Boc-NH-PEG3-propargyl	Others	Others
	Boc-NH-PEG3-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14822	Bromoacetamido-PEG3-NH-Boc	Others	Others
	Bromoacetamido-PEG3-NH-Boc is a polyethylene glycol (PEG)-based linker compound employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T15292	Fluorescein-PEG3-NH-Boc	Others	Others
	Fluorescein-PEG3-NH-Boc is a polyethylene glycol (PEG)-based proteolysis-targeting chimera (PROTAC) linker utilized for the synthesis of PROTACs[1].
T39925	Thalidomide-NH-PEG3-COOH Thalidomide-NH-PEG3-COOH
	Thalidomide-NH-PEG3-COOH is a conjugate of the E3 ligase ligand-linker synthesized compound, which integrates a cereblon ligand based on Thalidomide and a linker employed in PROTAC technology.
T16303	NH-bis(PEG3-Boc)	Others	Others
	NH-bis(PEG3-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18482	NH-bis(PEG3-acid)	Others	Others
	NH-bis(PEG3-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15316	Fmoc-NH-PEG3-CH2CH2COOH	Others	Others
	Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T17972	Fmoc-NH-PEG3-C2-NH2	Others	Others
	Fmoc-NH-PEG3-C2-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17747	DBCO-C3-PEG4-NH-Boc	Others	Others
	DBCO-C3-PEG4-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14267	Aminooxy-PEG3-C2-NH-Boc	Others	Others
	Aminooxy-PEG3-C2-NH-Boc is a PEGylated PROTAC linker utilized in the synthesis of PROTACs, an emerging class of bifunctional molecules for targeted protein degradation[1].
T15225	endo-BCN-PEG3-NH-Boc	Others	Others
	endo-BCN-PEG3-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14888	Cbz-NH-PEG3-C2-acid	Others	Others
	Cbz-NH-PEG3-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14308	APN-C3-NH-Boc tert-Butyl 3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylcarbamate	Others	Others
	APN-C3-NH-Boc is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14743	Boc-NH-PEG3-sulfonic acid	Others	Others
	Boc-NH-PEG3-sulfonic acid is a polyethylene glycol (PEG) derived linker used for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17956	Fmoc-N-bis-PEG3-NH-Boc	Others	Others
	Fmoc-N-bis-PEG3-NH-Boc is a cleavable ADC linker compound consisting of three PEG units, employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T18562	Propargyl-NH-PEG3-C2-NHS ester	Others	Others
	Propargyl-NH-PEG3-C2-NHS ester is a non-cleavable triethylene glycol linker with propargyl and N-hydroxysuccinimide functional groups. It is utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T18630	Tos-PEG3-NH-Boc PROTAC Linker 9	Others	Others
	Tos-PEG3-NH-Boc (PROTAC Linker 9) is a PEG-based linker utilized for the synthesis of PROTACs. It plays a critical role in facilitating the connection between a target protein and an E3 ubiquitin ligase, ultimately leading to the degradation of the target protein.
T16193	N-(Azido-PEG3)-NH-PEG3-acid	Others	Others
	N-(Azido-PEG3)-NH-PEG3-acid is a polyethylene glycol (PEG) derived linker utilized for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T38591	Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA)
	Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker, utilized for synthesizing PROTACs.
T17676	Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA	Others	Others
	Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double claevable 3-unit and 4-unit PEG linker for antibody-drug-conjugation (ADC).
T18384	N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid	Others	Others
	N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a polyethylene glycol (PEG)-based linker for the development of proteolysis targeting chimeras (PROTACs)[1].
T19511	PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	Others	Others
	PGlu-3-methyl-His-Pro-NH2 TFA, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.
T40023	Pomalidomide-PEG3-CO2H Thalidomide-NH-PEG3-propionic acid	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Pomalidomide-PEG3-CO2H (Thalidomide-NH-PEG3-propionic acid) 是一种由 E3 连接酶配体和连接体组成的偶联物，结合了基于 Thalidomide 的 Cereblon 配体和 3 个单元 PEG Linker。
TNU1260	N6-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-(2-methoxyethyl)adenosine
	Nucleoside Derivatives - 3’-Modified nucleosides; Protected nucleosides w/NH/OH open
T65396	Piperazine 2HCl
	Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspected toxicoses in cats. Piperazine neurotoxicity in cats and dogs usually was manifested by muscle tremors, ataxia, and/or behavioral disturbances within 24 hours after estimated daily dose(s) between 20 and 110 mg/kg[1]. For di-substituted derivatives, ciprofloxacin was selected an...

化合物

Cat.No: T40548

Target: Thyroid hormone receptor(THR)

NH-bis(PEG3-azide)

Cat.No: T16302

Target: Others

Cbz-NH-PEG3-CH2COOH

Cat.No: T17722

Synonym: 苯甲氧羰酰基二聚乙二醇羧乙基

Target: Others, PROTAC Linker

Boc-NH-PEG3-CH2COOH

Cat.No: T14741

Synonym: 5,8,11-三氧杂-2-氮杂十三烷二酸 1-叔丁酯

Target: PROTAC Linker

Boc-NH-PEG3-NHS ester

Cat.No: T17677

Synonym: 氨基叔丁酯-三聚乙二醇-NHS 酯

Target: Others, PROTAC Linker

Thalidomide-NH-PEG1-NH2 hydrochloride

Cat.No: T9401

Synonym: 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide-NH-CH2-COOH

Cat.No: T40016

Synonym: 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine

Target: Ligand for E3 Ligase

Cat.No: T7701

Synonym: PROTAC Linker 10,2-[2-(2-T-BOC-氨基乙氧基)乙氧基]乙醇

Target: Others, PROTAC Linker

Thalidomide-NH-C2-PEG3-OH

Cat.No: T9382

Synonym: H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-

Target: E3 Ligase Ligand-Linker Conjugate

Cat.No: T16305

Target: Others

NH-bis(PEG3-C2-NH-Boc)

Cat.No: T16304

Target: Others

Boc-NH-PEG3-propargyl

Cat.No: T14742

Target: Others

Bromoacetamido-PEG3-NH-Boc

Cat.No: T14822

Target: Others

Fluorescein-PEG3-NH-Boc

Cat.No: T15292

Target: Others

Thalidomide-NH-PEG3-COOH

Cat.No: T39925

Synonym: Thalidomide-NH-PEG3-COOH

NH-bis(PEG3-Boc)

Cat.No: T16303

Target: Others

NH-bis(PEG3-acid)

Cat.No: T18482

Target: Others

Fmoc-NH-PEG3-CH2CH2COOH

Cat.No: T15316

Target: Others

Fmoc-NH-PEG3-C2-NH2

Cat.No: T17972

Target: Others

DBCO-C3-PEG4-NH-Boc

Cat.No: T17747

Target: Others

Aminooxy-PEG3-C2-NH-Boc

Cat.No: T14267

Target: Others

endo-BCN-PEG3-NH-Boc

Cat.No: T15225

Target: Others

Cbz-NH-PEG3-C2-acid

Cat.No: T14888

Target: Others

Cat.No: T14308

Synonym: tert-Butyl 3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylcarbamate

Target: Others

Boc-NH-PEG3-sulfonic acid

Cat.No: T14743

Target: Others

Fmoc-N-bis-PEG3-NH-Boc

Cat.No: T17956

Target: Others

Propargyl-NH-PEG3-C2-NHS ester

Cat.No: T18562

Target: Others

Tos-PEG3-NH-Boc

Cat.No: T18630

Synonym: PROTAC Linker 9

Target: Others

N-(Azido-PEG3)-NH-PEG3-acid

Cat.No: T16193

Target: Others

Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA)

Cat.No: T38591

Synonym: Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA)

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA

Cat.No: T17676

Target: Others

N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid

Cat.No: T18384

Target: Others

PGlu-3-methyl-His-Pro-NH2 TFA

Cat.No: T19511

Synonym: A-42872 TFA

Target: Others

Pomalidomide-PEG3-CO2H

Cat.No: T40023

Synonym: Thalidomide-NH-PEG3-propionic acid

Target: E3 Ligase Ligand-Linker Conjugate

N6-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-(2-methoxyethyl)adenosine

Cat.No: TNU1260

Piperazine 2HCl

Cat.No: T65396

Cat. No.	Product Name	Target	Signaling Pathways
T4866	H-Trp-NH2.HCl L-Tryptophanamide hydrochloride,L-色氨酰胺盐酸盐,(2S)-2-amino-3-(1H-indol-3-yl)propanamide hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	H-Trp-NH2.HCl ((2S)-2-amino-3-(1H-indol-3-yl)propanamide hydrochloride) 是一种内源性代谢产物，已在多种生物体液中检测到，如尿液和血液。
TWS1977	Kamebakaurin 尾叶香茶菜丙素,Kamebakaurine	NF-κB	NF-κB
	Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物，是一种NF-κB 的抑制剂，能够抑制 p50 的 DNA 结合活性。

天然产物

Cat.No: T4866

Synonym: L-Tryptophanamide hydrochloride,L-色氨酰胺盐酸盐,(2S)-2-amino-3-(1H-indol-3-yl)propanamide hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: TWS1977

Synonym: 尾叶香茶菜丙素,Kamebakaurine

Target: NF-κB

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