61
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40548 |
NH-3
|
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
NH-3是一种高效的口服活性甲状腺激素受体(THR)拮抗剂,具有可逆行为,其IC 50为55 nM。NH-3源自选择性甲状腺激素模拟物GC-1,有效地抑制甲状腺激素与相应受体的结合,从而阻碍辅因子的招募。 | |||
T16302 |
NH-bis(PEG3-azide)
|
Others | Others |
NH-bis(PEG3-azide) 是一种属于 PEG 类的 PROTAC 连接体,可用于合成 PROTAC 分子。 | |||
T39925 |
Thalidomide-NH-PEG3-COOH
Thalidomide-NH-PEG3-COOH |
||
Thalidomide-NH-PEG3-COOH is a conjugate of the E3 ligase ligand-linker synthesized compound, which integrates a cereblon ligand based on Thalidomide and a linker employed in PROTAC technology. | |||
T17722 |
Cbz-NH-PEG3-CH2COOH
苯甲氧羰酰基二聚乙二醇羧乙基 |
Others; PROTAC Linker | Others; PROTAC |
Cbz-NH-PEG3-CH2COOH 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T14741 |
Boc-NH-PEG3-CH2COOH
5,8,11-三氧杂-2-氮杂十三烷二酸 1-叔丁酯 |
PROTAC Linker | PROTAC |
Boc-NH-PEG3-CH2COOH 是基于 PEG 的 PROTAC linker,用于合成 PROTAC。 | |||
T17677 |
Boc-NH-PEG3-NHS ester
氨基叔丁酯-三聚乙二醇-NHS 酯 |
Others; PROTAC Linker | Others; PROTAC |
Boc-NH-PEG3-NHS ester 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T38591 |
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA)
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) |
||
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker, utilized for synthesizing PROTACs. | |||
T9401 |
Thalidomide-NH-PEG1-NH2 hydrochloride
4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成。 | |||
T40016 |
Thalidomide-NH-CH2-COOH
2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine |
Ligand for E3 Ligase | PROTAC |
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T7701 |
Boc-NH-PEG3
PROTAC Linker 10,2-[2-(2-T-BOC-氨基乙氧基)乙氧基]乙醇 |
Others; PROTAC Linker | Others; PROTAC |
Boc-NH-PEG3 (PROTAC Linker 10) 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 的合成分子。 | |||
T9382 |
Thalidomide-NH-C2-PEG3-OH
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是 E3 连接酶配体-linker 偶联物,可用于合成 PROTAC BCL-XL 降解剂 XZ739。 | |||
T40002 |
Pomalidomide-C3-NH2 hydrochloride
|
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Pomalidomide-C3-NH2 hydrochloride 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker,是合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成。 | |||
T7760 |
Thalidomide-O-amido-C3-NH2 TFA
Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA |
E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | PROTAC |
Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T16305 |
NH-bis-PEG3
|
Others | Others |
NH-bis-PEG3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T16304 |
NH-bis(PEG3-C2-NH-Boc)
|
Others | Others |
NH-bis(PEG3-C2-NH-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14742 |
Boc-NH-PEG3-propargyl
|
Others | Others |
Boc-NH-PEG3-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14822 |
Bromoacetamido-PEG3-NH-Boc
|
Others | Others |
Bromoacetamido-PEG3-NH-Boc is a polyethylene glycol (PEG)-based linker compound employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1]. | |||
T15292 |
Fluorescein-PEG3-NH-Boc
|
Others | Others |
Fluorescein-PEG3-NH-Boc is a polyethylene glycol (PEG)-based proteolysis-targeting chimera (PROTAC) linker utilized for the synthesis of PROTACs[1]. | |||
T16303 |
NH-bis(PEG3-Boc)
|
Others | Others |
NH-bis(PEG3-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18482 |
NH-bis(PEG3-acid)
|
Others | Others |
NH-bis(PEG3-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T15316 | Fmoc-NH-PEG3-CH2CH2COOH | Others | Others |
Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T17972 |
Fmoc-NH-PEG3-C2-NH2
|
Others | Others |
Fmoc-NH-PEG3-C2-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17747 |
DBCO-C3-PEG4-NH-Boc
|
Others | Others |
DBCO-C3-PEG4-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14267 |
Aminooxy-PEG3-C2-NH-Boc
|
Others | Others |
Aminooxy-PEG3-C2-NH-Boc is a PEGylated PROTAC linker utilized in the synthesis of PROTACs, an emerging class of bifunctional molecules for targeted protein degradation[1]. | |||
T15225 |
endo-BCN-PEG3-NH-Boc
|
Others | Others |
endo-BCN-PEG3-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14888 |
Cbz-NH-PEG3-C2-acid
|
Others | Others |
Cbz-NH-PEG3-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14308 |
APN-C3-NH-Boc
tert-Butyl 3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylcarbamate |
Others | Others |
APN-C3-NH-Boc is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14743 |
Boc-NH-PEG3-sulfonic acid
|
Others | Others |
Boc-NH-PEG3-sulfonic acid is a polyethylene glycol (PEG) derived linker used for the synthesis of proteolysis-targeting chimeras (PROTACs)[1]. | |||
T17956 |
Fmoc-N-bis-PEG3-NH-Boc
|
Others | Others |
Fmoc-N-bis-PEG3-NH-Boc is a cleavable ADC linker compound consisting of three PEG units, employed in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T18562 |
Propargyl-NH-PEG3-C2-NHS ester
|
Others | Others |
Propargyl-NH-PEG3-C2-NHS ester is a non-cleavable triethylene glycol linker with propargyl and N-hydroxysuccinimide functional groups. It is utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T18630 |
Tos-PEG3-NH-Boc
PROTAC Linker 9 |
Others | Others |
Tos-PEG3-NH-Boc (PROTAC Linker 9) is a PEG-based linker utilized for the synthesis of PROTACs. It plays a critical role in facilitating the connection between a target protein and an E3 ubiquitin ligase, ultimately leading to the degradation of the target protein. | |||
T16193 |
N-(Azido-PEG3)-NH-PEG3-acid
|
Others | Others |
N-(Azido-PEG3)-NH-PEG3-acid is a polyethylene glycol (PEG) derived linker utilized for the synthesis of proteolysis targeting chimeras (PROTACs)[1]. | |||
T17676 |
Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA
|
Others | Others |
Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double claevable 3-unit and 4-unit PEG linker for antibody-drug-conjugation (ADC). | |||
T18384 |
N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid
|
Others | Others |
N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a polyethylene glycol (PEG)-based linker for the development of proteolysis targeting chimeras (PROTACs)[1]. | |||
T41071 |
NH2-PEG3 hydrochloride
NH2-PEG3 hydrochloride |
||
NH2-PEG3 hydrochloride is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T39379 |
Thalidomide-PEG3-NH2
Thalidomide-PEG3-NH2 |
||
Thalidomide-PEG3-NH2 is a synthesized conjugate comprising an E3 ligase ligand-linker conjugate that integrates a cereblon ligand based on Thalidomide and a linker employed in PROTAC technology. | |||
T39952 |
Pomalidomide-amino-PEG3-NH2
Pomalidomide-amino-PEG3-NH2 |
||
Pomalidomide-amino-PEG3-NH2 is a compound obtained through synthesis, consisting of a conjugation between the E3 ligase ligand linker and Pomalidomide, a cereblon ligand. This compound is specifically designed for application in PROTAC technology, incorporating a linker that enables effective binding with the targeted proteins. | |||
T39895 |
Thalidomide-Piperazine-PEG3-NH2
Thalidomide-Piperazine-PEG3-NH2 |
||
Thalidomide-Piperazine-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that combines the Thalidomide-based cereblon ligand with a linker commonly used in PROTAC technology, serving as an E3 ligase recruiter. | |||
T38549 |
Azido-C1-PEG3-C3-NH2
Azido-C1-PEG3-C3-NH2 |
||
Azido-C1-PEG3-C3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T39426 |
Thalidomide-O-amido-C3-NH2
Thalidomide-O-amido-C3-NH2,Cereblon Ligand-Linker Conjugates 16,E3LigaseLigand-LinkerConjugates52 |
||
Thalidomide-O-amido-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate, which combines the cereblon ligand derived from Thalidomide with a linker utilized in PROTAC technology. | |||
T39953 |
Pomalidomide-amino-PEG3-NH2 hydrochloride
Pomalidomide-amino-PEG3-NH2 hydrochloride |
||
Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthetic conjugate compound incorporating the cereblon ligand from Pomalidomide and a linker commonly utilized in PROTAC technology. This compound functions as an E3 ligase ligand-linker conjugate in biochemical reactions. | |||
T39894 |
Thalidomide-4-C3-NH2 hydrochloride
Thalidomide-4-C3-NH2 hydrochloride |
||
Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived cereblon ligand utilized for the recruitment of CRBN protein. This compound can be linked to the ligand for protein using a linker to create PROTACs. | |||
T38661 |
NH2-PEG3-C6-Cl
NH2-PEG3-C6-Cl |
||
NH2-PEG3-C6-Cl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T39360 |
N-Boc-C1-PEG3-C3-NH2
N-Boc-C1-PEG3-C3-NH2 |
||
N-Boc-C1-PEG3-C3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T19511 |
PGlu-3-methyl-His-Pro-NH2 TFA
A-42872 TFA |
Others | Others |
PGlu-3-methyl-His-Pro-NH2 TFA, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. | |||
T38671 |
m-PEG2-O-Ph-3-NH2
m-PEG2-O-Ph-3-NH2 |
||
m-PEG2-O-Ph-3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T39215 |
Thalidomide-O-amido-C3-PEG3-C1-NH2
Thalidomide-O-amido-C3-PEG3-C1-NH2 |
||
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized conjugate compound that serves as an E3 ligase ligand-linker. It features a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology. | |||
T40105 |
Pomalidomide-PEG3-C2-NH2 hydrochloride
Pomalidomide-PEG3-C2-NH2 hydrochloride,Cereblon Ligand-Linker Conjugates 5 hydrochloride,E3ligaseLigand-LinkerConjugates30hydrochloride |
||
Pomalidomide-PEG3-C2-NH2 hydrochloride, also known as Cereblon Ligand-Linker Conjugate 5, is a chemically synthesized E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand based on Pomalidomide and a linker commonly employed in PROTAC technology. | |||
T40343 |
CC-885-CH2-PEG1-NH-CH3
CC-885-CH2-PEG1-NH-CH3 |
||
CC-885-CH2-PEG1-NH-CH3 is a neoDegrader compound employed for the production of Antibody neoDegrader Conjugate (AnDC) during synthesis. | |||
T41115 |
N-Boc-C1-PEG5-C3-NH2
N-Boc-C1-PEG5-C3-NH2 |
||
N-Boc-C1-PEG5-C3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4866 |
H-Trp-NH2.HCl
L-Tryptophanamide hydrochloride,L-色氨酰胺盐酸盐,(2S)-2-amino-3-(1H-indol-3-yl)propanamide hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
H-Trp-NH2.HCl ((2S)-2-amino-3-(1H-indol-3-yl)propanamide hydrochloride) 是一种内源性代谢产物,已在多种生物体液中检测到,如尿液和血液。 | |||
TWS1977 |
Kamebakaurin
尾叶香茶菜丙素,Kamebakaurine |
NF-κB | NF-κB |
Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。 |