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Search Results for " nfkb "

Targets Recommended: Others

4

抑制剂 & 化合物

1

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9127	MYLS22	Others	Others
	MYLS22 是视神经萎缩 1 的选择性抑制剂。它通过影响 NFkB 活性和血管生成基因表达抑制血管生成，靶向作用于内皮细胞 OPA1 ，减少肿瘤的生长。
T25150	BI-69A11 BI 69A11,(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one	NF-κB; Akt	Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling
	BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) 是一种双重 AKT 和 NFkB 通路抑制剂。它通过靶向 Akt 增强结肠癌细胞对 mda-7/IL-24 诱导的生长抑制的敏感性。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T70733	APX2009
	APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell proliferation and induces cell cycle arrest.

化合物

Cat.No: T9127

Target: Others

Cat.No: T25150

Synonym: BI 69A11,(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one

Target: NF-κB, Akt

Cat.No: T15017

Target: TLR

Cat.No: T70733

Cat. No.	Product Name	Target	Signaling Pathways
T3S2296	Gardenoside 羟异栀子苷,栀子苷	Others	Others
	Gardenoside 是一种发现于栀子中的天然化合物，具有保肝作用。它对 FFA 诱导的细胞脂肪变性有抑制作用。它可以调节 P2X3 和 P2X7 受体来抑制慢性缩痛。

天然产物

Cat.No: T3S2296

Synonym: 羟异栀子苷,栀子苷

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05800	IKB beta/NFKBIB Protein, Human, Recombinant (GST) NFKB inhibitor β,NFKB inhibitor beta,TRIP9...	Human	E. coli
	NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. NF-kappaB regulation involves the inhibitor pr...
TMPK-00723	RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) CD265,Rank,FEO,ODFR,NF-KB,OSTS,TNFRSF11A,OPTB7,NFKB...	Mouse	HEK293 Cells
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 47.0 kDa and the acce...
TMPK-00351	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) NF-KB,ODFR,PDB2,Rank,OSTS,NFKB,OPTB7,TNFRSF11A,LOH1...	Human	HEK293 Cells
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.85 kDa ...
TMPJ-00674	RANK/TNFRSF11A Protein, Mouse, Recombinant (His) Receptor activator of NF-KB,TNFRSF11A,Osteoclast differentia...	Mouse	HEK293 Cells
	Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br...
TMPY-02387	NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST) NFKB3,p65,v-rel avian reticuloendotheliosis viral o...	Human	E. coli
	RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an eff...
TMPJ-00887	NFKB1 Protein, Human, Recombinant (His) Nuclear factor of κ light polypeptide gene enhancer in B-cel...	Human	E. coli
	The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory...
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His) IkB α,IKBA,nuclear factor of kappa light polypeptide gene en...	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper function...
TMPK-01298	BST2 Protein, Cynomolgus, Recombinant (His) HM1.24 antigen,PDCA-1,BST2,TETHERIN,BST-2,NPC-A-7,CD317	Cynomolgus	HEK293 Cells
	Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by tethering enveloped virions to the cell surface to restrict viral release and by inducing the NFKB-dependent antiviral immune response. BST2 expression was significantly increased during porcine epidemic diarrhea virus (PEDV) infection of Vero cells by IRF1 targeting its promoter. Both the BST2 and N protein interacted with the E3 ubiquitin ligase MARCHF8/MARCH8 and the cargo receptor.

重组蛋白

IKB beta/NFKBIB Protein, Human, Recombinant (GST)

Cat.No: TMPY-05800

Species: Human

Expression System: E. coli

RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00723

Species: Mouse

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)

Cat.No: TMPK-00351

Species: Human

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00674

Species: Mouse

Expression System: HEK293 Cells

NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST)

Cat.No: TMPY-02387

Species: Human

Expression System: E. coli

NFKB1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00887

Species: Human

Expression System: E. coli

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

Cat.No: TMPY-01710

Species: Human

Expression System: E. coli

BST2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01298

Species: Cynomolgus

Expression System: HEK293 Cells

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