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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6442 |
CH5138303
|
HSP | Cytoskeletal Signaling; Metabolism |
CH5138303 是一种可口服的 Hsp90 抑制剂,Kd 为 0.48 nM。 | |||
T34602 |
Selatinib
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Selatinib 是一种具有口服活性和有效性的 EGFR 和 ErbB2 双重抑制剂,具有抗癌活性,抑制 NCI-N87 肿瘤细胞生长。 | |||
T82802 |
BX-2819
|
HSP | Cytoskeletal Signaling; Metabolism |
BX-2819为一种Hsp90抑制剂,具有41 nM 的IC50值,能有效抑制癌细胞增殖,并在裸鼠模型中显著抑制NCI-N87和HT-29肿瘤生长。 | |||
T36684 | Ipivivint | ||
Ipivivint, a first-in-class, orally active and potent CDC-like kinase (CLK) inhibitor, inhibits CLK1 (IC50=1.4 μM), CLK2 (IC50=0.002 μM) and CLK3 (IC50=0.022 μM). Ipivivint reduces Wnt pathway signaling gene expression through inhibiting CLK activity and serine and arginine rich splicing factor (SRSF) phosphorylation and disrupting spliceosome activity. Ipivivint can be used for the research of cancer[1]. Ipivivint (SW480 cells; 0.01~10 μM; 1 hour) potently inhibits SRSF5/6 phosphorylation[1].Ip... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN3495 | Benzyl ferulate | TNF; Antifection | Apoptosis; Microbiology/Virology |
Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE-30 oesophageal squamous cancer, and NCI-N87 gastric carcinoma). |