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12

抑制剂 & 化合物

2

天然产物

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Cat. No. Product Name Target Signaling Pathways
T6133 Remodelin hydrobromide

Remodelin,Remodelin HBR

RAAS; Histone Acetyltransferase Chromatin/Epigenetic; Endocrinology/Hormones
Remodelin hydrobromide (Remodelin HBR) 是一种新型有效的选择性乙酰转移酶蛋白 NAT10 抑制剂,能改善早衰综合征细胞表型。
T40194 MeAIB

α-(Methylamino)isobutyric acid

Others Others
MeAIB 是一种n -乙酰转移酶抑制剂,抑制SNAT2相关信号通路。MeAIB 是氨基酸转运系统a (ATA1)的特异性底物。氨基酸转运系统a (ATA1)以Na+流动调控短链中性氨基酸的摄取。
T40411 ANAT inhibitor-1

ANAT Inhibitor-1 serves as an inhibitor of human aspartate N-acetyltransferase (ANAT), targeting Canavan disease.
T71535 GlmU-IN-5175178

GlmU-IN-5175178 is an inhibitor of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU).
T33477 Monosodium N-acetylglutamate

Sodium N-acetylglutamate (1:1)

Monosodium N-acetylglutamate is the sodium salt of N-acetylglutamate, biosynthesized from glutamate and acetylornithine by ornithine acetyltransferase, and from glutamic acid and acetyl-CoA by the enzyme N-acetylglutamate synthase.
T35820 CAY10685

CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 that contains an alkyne moiety for use in click chemistry reactions. Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture associated with cancer and certain laminopathies.
T10135 4-Acetamidophenyl acetate

Others Others
4-Acetamidophenyl acetate is an impurity of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50: 25.8 μM) and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
T81712 Naa50-IN-1

Naa50-IN-1 (化合物 4a),作为N-α-Acetyltransferase 50 (Naa50) 的特异性抑制剂,展现出IC50为7 mM的活性,并具备作为癌症研究潜力候选物的特征。
T61238 NAT2-IN-1

NAT2-IN-1 (APA) 是药物代谢酶 N-乙酰转移酶 2 (NAT2) 的抑制剂。NAT2-IN-1 可以选择性地杀死慢速 NAT2 细胞。
T70805 Diethylnorspermine HBr

Diethylnorspermine, also known as DENSPM, BE-333, DE-333 and N(1),N(11)-Diethylnorspermine, is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed polyamines (PAs) analog which induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells..
T78352 N-acetylglucosamine-1-P uridyltransferase (AGX1)

GlcNAc1pUT

N-acetylglucosamine-1-P uridyltransferase (AGX1) (GlcNAc1pUT) 是具有双功能乙酰转移酶/尿苷转移酶活性的原核生物专有酶。该酶能结合GlcNAc-1-P与UTP,催化合成UDP-GlcNAc的尿苷酰转移反应。
T35681 MeIQx

MeIQx (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1It is activated by hydroxylation and subsequent O-acetylationviathe cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3

化合物

Remodelin hydrobromide
Cat.No: T6133
Synonym: Remodelin,Remodelin HBR
Target: RAAS, Histone Acetyltransferase
MeAIB
Cat.No: T40194
Synonym: α-(Methylamino)isobutyric acid
Target: Others
ANAT inhibitor-1
Cat.No: T40411
Synonym:
Target:
GlmU-IN-5175178
Cat.No: T71535
Synonym:
Target:
Monosodium N-acetylglutamate
Cat.No: T33477
Synonym: Sodium N-acetylglutamate (1:1)
Target:
CAY10685
Cat.No: T35820
Synonym:
Target:
4-Acetamidophenyl acetate
Cat.No: T10135
Synonym:
Target: Others
Naa50-IN-1
Cat.No: T81712
Synonym:
Target:
NAT2-IN-1
Cat.No: T61238
Synonym:
Target:
Diethylnorspermine HBr
Cat.No: T70805
Synonym:
Target:
N-acetylglucosamine-1-P uridyltransferase (AGX1)
Cat.No: T78352
Synonym: GlcNAc1pUT
Target:
MeIQx
Cat.No: T35681
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T1354 N-Acetyl-5-hydroxytryptamine

Normelatonin,N-乙酰-5-羟色胺,O-Demethylmelatonin,N-Acetylserotonin

Trk receptor; Endogenous Metabolite Metabolism; Tyrosine Kinase/Adaptors
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体,能够有效激活TrkB 受体。
T4781 N-Acetyl-L-phenylalanine

N-Ac-Phenylalanine,N-乙酰-L-苯丙氨酸

Others; Endogenous Metabolite Metabolism; Others
N-Acetyl-L-phenylalanine (N-Ac-Phenylalanine) 是一种大肠杆菌中的主要酰基氨基酸,由 L-苯丙氨酸和乙酰辅酶 A 合成。

天然产物

N-Acetyl-5-hydroxytryptamine
Cat.No: T1354
Synonym: Normelatonin,N-乙酰-5-羟色胺,O-Demethylmelatonin,N-Acetylserotonin
Target: Trk receptor, Endogenous Metabolite
N-Acetyl-L-phenylalanine
Cat.No: T4781
Synonym: N-Ac-Phenylalanine,N-乙酰-L-苯丙氨酸
Target: Others, Endogenous Metabolite
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