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Search Results for " maytansine "

13

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T80884	Val-Cit-amide-Ph-Maytansine
	Val-Cit-amide-Ph-Maytansine 是用于肝细胞生长因子受体 c-Met (MET) 或抗体药物偶联物 (ADCs) 的抗体和双特异性抗原结合分子。
T80885	Val-Cit-amide-Cbz-N(Me)-Maytansine
	Val-Cit-amide-Cbz-N(Me)-Maytansine是一种可用于构建抗体和双特异性抗原结合分子，能够特异性结合肝细胞生长因子受体c-Met (MET)以及用于制备抗体药物偶联物(antibody-drug conjugates) (ADCs)的化合物。
T21408	DM1-SMe DM1-SSMe	Microtubule Associated	Cytoskeletal Signaling
	DM1-SMe (DM1-SSMe) 是美登木素微管的有效抑制剂。 DM1-SMe 的效力是母体药物美登素的 3 至 10 倍，在一组人类肿瘤细胞系中，DM1-SMe 的 IC50 为 0.003 至 0.01 nM。
T1992	Mertansine DM1,Maytansinoid DM1	Microtubule Associated	Cytoskeletal Signaling
	Mertansine (DM1) 是一种微管蛋白抑制剂，也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上，形成抗体偶联药物。
T13766	Maytansinoid DM4	Others	Others
	Maytansinoid DM4, a thiol-containing maytansine derivative, is a highly potent cytotoxic moiety utilized in ADC applications.
T12805	S-methyl DM1	Microtubule Associated	Cytoskeletal Signaling
	S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.
T11057	DM3-SMe	Others	Others
	DM3-SMe is a maytansine derivative and tubulin inhibitor. It is a cytotoxic part of antibody-drug conjugates (ADCs) and can bind to antibodies via disulfide bonds or stable thioether bonds. DM3-SMe has high cytotoxic activity in vitro with IC50 of 0.0011
T18701	SPDB-DM4	Others	Others
	SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates significant anti-tumor efficacy.
T18730	sulfo-SPDB-DM4	Others	Others
	Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker.
T11058	DM3 Maytansinoid DM3	Others	Others
	DM3 (Maytansinoid DM3) is a maytansine mimic containing disulfide or thiol groups and a tubulin inhibitor. It is the cytotoxic part of antibody-drug conjugates (ADCs) .
T36647	Trastuzumab emtansine	Others	Others
	Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory derivative of maytansine. This compound is utilized in the investigation of advanced breast cancer[1][2].
T17832	DM1-PEG4-DBCO	Others	Others
	DM1-(PEG)4-DBCO is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (DM1) with the DBCO-PEG4-Ahx linker for the development of antibody-drug conjugates (ADCs). This conjugation aims to mitigate the systemic toxicity associated with maytansine while improving tumor-specific delivery, leveraging DM1’s capabilities as an antibody-conjugatable maytansinoid.
T76939	Cantuzumab mertansine
	Cantuzumab mertansine (SB-408075; huC242-DM1) 是一种ADC，是强效美登素衍生物 (DM1) 和针对 CanAg 的人源化单克隆抗体 (huC242) 的免疫偶联物。Cantuzumab mertansine 对结肠癌细胞具有细胞毒性，并且对一系列 CanAg 阳性人肿瘤异种移植物具有广泛的抗肿瘤活性。

化合物

Val-Cit-amide-Ph-Maytansine

Cat.No: T80884

Val-Cit-amide-Cbz-N(Me)-Maytansine

Cat.No: T80885

Cat.No: T21408

Synonym: DM1-SSMe

Target: Microtubule Associated

Cat.No: T1992

Synonym: DM1,Maytansinoid DM1

Target: Microtubule Associated

Maytansinoid DM4

Cat.No: T13766

Target: Others

Cat.No: T12805

Target: Microtubule Associated

Cat.No: T11057

Target: Others

Cat.No: T18701

Target: Others

Cat.No: T18730

Target: Others

Cat.No: T11058

Synonym: Maytansinoid DM3

Target: Others

Trastuzumab emtansine

Cat.No: T36647

Target: Others

Cat.No: T17832

Target: Others

Cantuzumab mertansine

Cat.No: T76939

Cat. No.	Product Name	Target	Signaling Pathways
T21351	Maytansine NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新	Microtubule Associated; Antibiotic	Cytoskeletal Signaling; Microbiology/Virology
	Maytansine (NSC-153858) 是从变叶美登木中分离的一种高效微管靶向天然产物，可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。

天然产物

Cat.No: T21351

Synonym: NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新

Target: Microtubule Associated, Antibiotic

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