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Search Results for " mmp8 "

Targets Recommended: MMP

12

抑制剂 & 化合物

2

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10597	BR351	MMP	Proteases/Proteasome
	BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).
T10598	BR351 precursor	Others	Others
	BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).
T61271	MMP2-IN-3	MMP	Proteases/Proteasome
	MMP2-IN-3是一种有效的基质金属蛋白酶（MMP-2）抑制剂（ IC50 值：31 μM）。MMP2-IN-3 抑制 MMP-9 和 MMP-8 ，其 IC50 分别为 26.6 和 32 μM。
T12414	PF-00356231 hydrochloride	MMP	Proteases/Proteasome
	PF-00356231 hydrochloride 是基质金属蛋白酶 MMP-12 的抑制剂，IC50 为 1.4 μM。
T2743	Ilomastat Galardin,GM6001,伊洛马司他	MMP	Proteases/Proteasome
	Ilomastat (GM6001) 是广谱的基质金属蛋白酶 (MMP) 抑制剂，可抑制 MMP 的活性，IC50值分别为 1.5 nM (MMP-1)，1.1 nM (MMP-2)，1.9 nM (MMP-3)，0.5 nM (MMP-9)，对人皮肤成纤维细胞胶原酶 (MMP-1) 的Ki=为 0.4 nM。
T27654	JG26 JG 26,JG-26	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	JG26 是一种强效的 ADAM17 抑制剂，对 ADAM8、ADAM17、ADAM10 和 MMP-12 均有抑制作用，其 IC50 值分别为 12 nM、1.9 nM、150 nM 和 9.4 nM，可用于研究机体免疫系统。
T13358	XL-784	MMP	Proteases/Proteasome
	XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T15015	CTS-1027 RS 130830,Ro 1130830	Others	Others
	CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.
T13357	XL-784 free base	Others	Others
	XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMP), (IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T13249	UK-370106	MMP	Proteases/Proteasome
	UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM).
T31063	CP-544439 UNII-516DO4KL5R
	CP-544439 is an inhibitor of matrix metalloproteinase-13, which has an effect on adipose tissue development.
T36492	CMC2.24
	CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis throug...

化合物

Cat.No: T10597

Target: MMP

BR351 precursor

Cat.No: T10598

Target: Others

Cat.No: T61271

Target: MMP

PF-00356231 hydrochloride

Cat.No: T12414

Target: MMP

Cat.No: T2743

Synonym: Galardin,GM6001,伊洛马司他

Target: MMP

Cat.No: T27654

Synonym: JG 26,JG-26

Target: MMP, Immunology/Inflammation related

Cat.No: T13358

Target: MMP

Cat.No: T15015

Synonym: RS 130830,Ro 1130830

Target: Others

XL-784 free base

Cat.No: T13357

Target: Others

Cat.No: T13249

Target: MMP

Cat.No: T31063

Synonym: UNII-516DO4KL5R

Cat.No: T36492

Cat. No.	Product Name	Target	Signaling Pathways
T3850	Luteolin 7-O-glucuronide Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷	MMP	Proteases/Proteasome
	Luteolin 7-O-glucuronide (Luteolin-7-glucuronide) 是一种自由基清除剂，能够抑制基质金属蛋白酶的活性，其对 MMP-1，MMP-3，MMP-8，MMP-9，MMP-13的IC50值分别为 17.63，7.99，11.42，12.85，0.03 μM。
T5S1026	Apigenin-7-glucuronide Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸	MMP	Proteases/Proteasome
	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性，其对 MMP-3 (IC50:12.87 μM)，MMP-8 (IC50:22.39 μM)，MMP-9 (IC50:17.52 μM)，MMP-13 (IC50:0.27 μM)。

天然产物

Luteolin 7-O-glucuronide

Cat.No: T3850

Synonym: Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷

Target: MMP

Apigenin-7-glucuronide

Cat.No: T5S1026

Synonym: Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸

Target: MMP

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01286	MMP-8 Protein, Cynomolgus, Recombinant (His) Collagenase 2,HNC,CLG1,MMP8,PMNL-CL	Cynomolgus	HEK293 Cells
	Alteration of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) expression has been studied for various cardiac diseases, including dilated cardiomyopathy (DCM), with the significance of surrogate markers of extracellular matrix (ECM) remodeling. MMP-8 was identified only in myocardiocytes, while MMP-9 and TIMP-2 were present in both myocardiocytes and stroma, but with different intensity. The increasing intensity of MMP-8 and TIMP-2 immunoreactions was signifi...
TMPY-01884	MMP-8 Protein, Human, Recombinant CLG1,HNC,PMNL-CL,matrix metallopeptidase 8,MMP<...	Human	HEK293 Cells
	MMP-8 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 52 kDa and the accession number is P22894.
TMPY-01377	MMP-8 Protein, Human, Recombinant (His) MMP-8,HNC,matrix metallopeptidase 8	Human	HEK293 Cells
	MMP-8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.6 kDa and the accession number is P22894.

重组蛋白

MMP-8 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01286

Species: Cynomolgus

Expression System: HEK293 Cells

MMP-8 Protein, Human, Recombinant

Cat.No: TMPY-01884

Species: Human

Expression System: HEK293 Cells

MMP-8 Protein, Human, Recombinant (His)

Cat.No: TMPY-01377

Species: Human

Expression System: HEK293 Cells

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