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Search Results for " mmp12 "

Targets Recommended: MMP

11

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T60083	MMP-12 Inhibitor MMP12,MMP408	MMP	Proteases/Proteasome
	MMP-12 Inhibitor 是一种选择性的 MMP-12 抑制剂，对人、小鼠、大鼠和绵羊 MMP-12 的 IC50 分别为 2、160、320 和 22.3 nM。
T27603	INCB3619 INCB-3619,INCB 3619	Immunology/Inflammation related	Immunology/Inflammation
	INCB3619 是一种具有选择性和高效性的 ADAM 的抑制剂，具有抗肿瘤作用，抑制 ADAM10、ADAM17、MMP12 和 MMP15。
T10474	BAY-7598	Others	Others
	BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).
T26720	AZD-6605 AZ11920155,AZ-11920155,AZD6605
	AZD6605 is a potent, reversible inhibitor of, MMP2, MMP9, MMP12 and MMP13.
T78181	MMP-7-IN-2	MMP; Others	Others; Proteases/Proteasome
	MMP-7-IN-2 可作为一种具有选择性和有效性的 MMP7 抑制剂，可用于研究炎症反应和与血管相关的疾病。
T12414	PF-00356231 hydrochloride	MMP	Proteases/Proteasome
	PF-00356231 hydrochloride 是基质金属蛋白酶 MMP-12 的抑制剂，IC50 为 1.4 μM。
T27654	JG26 JG 26,JG-26	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	JG26 是一种强效的 ADAM17 抑制剂，对 ADAM8、ADAM17、ADAM10 和 MMP-12 均有抑制作用，其 IC50 值分别为 12 nM、1.9 nM、150 nM 和 9.4 nM，可用于研究机体免疫系统。
T15015	CTS-1027 RS 130830,Ro 1130830	Others	Others
	CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.
T13249	UK-370106	MMP	Proteases/Proteasome
	UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM).
T31063	CP-544439 UNII-516DO4KL5R
	CP-544439 is an inhibitor of matrix metalloproteinase-13, which has an effect on adipose tissue development.
T36492	CMC2.24
	CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis throug...

化合物

MMP-12 Inhibitor

Cat.No: T60083

Synonym: MMP12,MMP408

Target: MMP

Cat.No: T27603

Synonym: INCB-3619,INCB 3619

Target: Immunology/Inflammation related

Cat.No: T10474

Target: Others

Cat.No: T26720

Synonym: AZ11920155,AZ-11920155,AZD6605

Cat.No: T78181

Target: MMP, Others

PF-00356231 hydrochloride

Cat.No: T12414

Target: MMP

Cat.No: T27654

Synonym: JG 26,JG-26

Target: MMP, Immunology/Inflammation related

Cat.No: T15015

Synonym: RS 130830,Ro 1130830

Target: Others

Cat.No: T13249

Target: MMP

Cat.No: T31063

Synonym: UNII-516DO4KL5R

Cat.No: T36492

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00942	MMP-12 Protein, Mouse, Recombinant (His) Mme,Mmp12,MMP-12,Mmel,Ma...	Mouse	HEK293 Cells
	Matrix metalloproteinase-12（MMP12） is a secreted protein.It contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic activity. It can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain) HME,ME,MMP-12,MME,matrix metallopeptidase ...	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ...

重组蛋白

MMP-12 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00942

Species: Mouse

Expression System: HEK293 Cells

MMP-12 Protein, Human, Recombinant (catalytic domain)

Cat.No: TMPY-02869

Species: Human

Expression System: E. coli

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