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Search Results for " mmp-ii "

Targets Recommended: MMP

3

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36712	BPHA MMP-2/MMP-9 Inhibitor II	MMP	Proteases/Proteasome
	BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂，对MMP-2、MMP-9 和 MMP-14 具有抑制作用，IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。
T62005	Imidapril
	Imidapril (TA-6366 free base) 是口服有效的血管紧张素转换酶（ACE）和MMP-9抑制剂。Imidapril 通过抑制血管紧张素 I 向血管紧张素 II 转化从而降低总外周阻力和血压。Imidapril 在高血压、1 型糖尿病、肾病和慢性心力衰竭中有研究价值。
T74501	NHEJ inhibitor-1
	NHEJ inhibitor-1 (Compound C2) 是一种三功能 Pt(II) 复合物，可缓解非同源末端连接 (NHEJ)/同源重组 (HR) 相关的双链断裂 (DSB) 修复，从而避免非小细胞肺对顺铂的耐药性。NHEJ inhibitor-1 抑制损伤修复蛋白 Ku70 和 Rad51，从而使肿瘤对活性分子重新敏感。NHEJ inhibitor-1 还诱导 ROS 产生和MMP 降低。

化合物

Cat.No: T36712

Synonym: MMP-2/MMP-9 Inhibitor II

Target: MMP

Cat.No: T62005

NHEJ inhibitor-1

Cat.No: T74501

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01477	MMP-2 Protein, Human, Recombinant TBE-1,MMP-II,matrix metallopeptidase 2,MON...	Human	HEK293 Cells
	MMP-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 72 kDa and the accession number is A0A024R6R4.
TMPJ-00447	MMP-3 Protein, Human, Recombinant (His) Transin-1,Stromelysin-1,MMP-3,Matrix metalloprotein...	Human	HEK293 Cells
	MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 c...
TMPJ-00957	MMP-9 Protein, Mouse, Recombinant (His) Matrix metalloproteinase-9,92 kDa gelatinase,GELB,Gelatinase...	Mouse	HEK293 Cells
	Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-9 (gelatinase B) can degrade a broad range of substrates including gelatin, collagen types IV and V, elastin and proteoglycan core protein. It is believed to act synergistically with interstitial collagenase (MMP1) in the degradation of fibrillar collagens as it degrades their denatured gelatin forms. MMP-9 is produced by ker...
TMPY-00886	MMP-1 Protein, Human, Recombinant (His) CLGN,CLG,matrix metallopeptidase 1	Human	HEK293 Cells
	MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and some bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP...
TMPJ-00159	EMMPRIN/CD147 Protein, Human, Recombinant (Avi & His), Biotinylated Membrane glycoprotein gp42,Basigin,HT7 antigen,Bsg,Basic imm...	Human	HEK293 Cells
	Basigin/CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore...
TMPY-02689	MMP-3 Protein, Human, Recombinant STMY,MMP-3,matrix metallopeptidase 3,CHDS6,STMY1,SL...	Human	E. coli
	Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in the extracellular matrix. This prot...

重组蛋白

MMP-2 Protein, Human, Recombinant

Cat.No: TMPY-01477

Species: Human

Expression System: HEK293 Cells

MMP-3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00447

Species: Human

Expression System: HEK293 Cells

MMP-9 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00957

Species: Mouse

Expression System: HEK293 Cells

MMP-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00886

Species: Human

Expression System: HEK293 Cells

EMMPRIN/CD147 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00159

Species: Human

Expression System: HEK293 Cells

MMP-3 Protein, Human, Recombinant

Cat.No: TMPY-02689

Species: Human

Expression System: E. coli

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