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Search Results for " mld "

Targets Recommended: Apoptosis HuR

7

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36493	CMLD-2	Apoptosis; HuR	Apoptosis; Chromatin/Epigenetic
	CMLD-2是一种 HuR-ARE 相互作用的抑制剂（Ki：350 nM），能竞争性地结合 HuR 蛋白并破坏其与富含腺嘌呤元素（ARE）的 mRNA 目标的相互作用。CMLD-2诱导细胞凋亡并通过 MAD2下调表现出抗肿瘤作用。CMLD-2 (1-75 μM ; 24-72 h) 对甲状腺癌细胞的活力具有抑制作用.CMLD-2 (20-30 μM ; 24-48 h) 激活 Caspases 并诱导H1299和A549细胞凋亡.CMLD-2 (30 μM ; 24-48 h) 诱导H1299和A549细胞的G1细胞周期停止和线粒体扰动。 CMLD-2（30μM；24-48小时）减少H1299细胞中HuR 和HuR 调节的mRNAs 和蛋白质的表达.CMLD-2（35μM；72小时）降低SW1736、8505C、BCPAP 和K1细胞的定向迁移能力。CMLD-2诱导SW1736、8505C、BCPAP 和K1细胞中的MAD2 mRNA 水平强烈下降。
T10848	CMLD012073	Others	Others
	CMLD012073 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits NIH/3T3 cells (IC50: 10 nM). CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).
T10847	CMLD012072	Others	Others
	CMLD012072 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor with potent anti-neoplastic activity. It can induce RNA clamping of eIF4A1 and eIF4A2.
T10846	CMLD010509 SDS-1-021	Others	Others
	CMLD010509 (SDS-1-021) is a highly selective inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MDM2, CCND1, MYC, MAF, and MCL-1.
T10849	CMLD012612	Others	Others
	CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).
T38184	C18:1 3'-sulfo Galactosylceramide (d18:1/18:1(9Z)) C18:1 3'-sulfo Galactosylceramide (d18:1/18:1(9Z))
	C18:1 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been found in mouse brain. It has been used as a standard for the quantification of C18:1 3'-sulfo galactosylceramide in dried blood spots from patients with metachromatic leukodystrophy (MLD) by UPLC-MS.
T38183	C18 3'-sulfo Galactosylceramide (d18:1/18:0) C18 3'-sulfo Galactosylceramide (d18:1/18:0)
	C18 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. Levels of short-chain sulfatides, including C18 3'-sulfo galactosylceramide, decrease with age in mice and humans. It is increased in brain from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions. Plasma levels of C18 3'-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability ...

化合物

Cat.No: T36493

Target: Apoptosis, HuR

Cat.No: T10848

Target: Others

Cat.No: T10847

Target: Others

Cat.No: T10846

Synonym: SDS-1-021

Target: Others

Cat.No: T10849

Target: Others

C18:1 3'-sulfo Galactosylceramide (d18:1/18:1(9Z))

Cat.No: T38184

Synonym: C18:1 3'-sulfo Galactosylceramide (d18:1/18:1(9Z))

C18 3'-sulfo Galactosylceramide (d18:1/18:0)

Cat.No: T38183

Synonym: C18 3'-sulfo Galactosylceramide (d18:1/18:0)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00669	ARSA Protein, Human, Recombinant (His) arylsulfatase A,MLD	Human	HEK293 Cells
	ARSA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.4 kDa and the accession number is P15289-1.
TMPK-01505	HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi), Biotinylated E7,MHC,HPV16	Human	HEK293 Cells
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KDEL) to the HPV16 E7-specific affibody.
TMPK-01504	HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Tetramer Protein, Human, MHC (His & Avi) MHC,HPV16,E7	Human	HEK293 Cells
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KDEL) to the HPV16 E7-specific affibody.
TMPK-01506	HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi) HPV16,E7,MHC	Human	HEK293 Cells
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KDEL) to the HPV16 E7-specific affibody.
TMPY-00209	PSAP/Prosaposin Protein, Rat, Recombinant (His) prosaposin	Rat	HEK293 Cells
	Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro...
TMPY-04510	PSAP/Prosaposin Protein, Human, Recombinant (His) prosaposin,SAP1,GLBA	Human	HEK293 Cells
	Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro...

重组蛋白

ARSA Protein, Human, Recombinant (His)

Cat.No: TMPY-00669

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01505

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01504

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01506

Species: Human

Expression System: HEK293 Cells

PSAP/Prosaposin Protein, Rat, Recombinant (His)

Cat.No: TMPY-00209

Species: Rat

Expression System: HEK293 Cells

PSAP/Prosaposin Protein, Human, Recombinant (His)

Cat.No: TMPY-04510

Species: Human

Expression System: HEK293 Cells

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