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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6591	Nodinitib-1 ML130,CID-1088438	TNF; NOD-like Receptor (NLR); NOD	Apoptosis; Immunology/Inflammation; NF-κB
	Nodinitib-1 (CID-1088438) 是 NOD1抑制剂(IC50:0.56 μM)。
T77063	Libivirumab
	Libivirumab (17.1.41) 是一种人源化抗HBV 单克隆抗体。Libivirumab 显示中和活性，对 HBsAg 和 HBeAg 的 IC50值分别为 35、130 ng/mL。
T36208	15(R)-Pinane Thromboxane A2 15(R)-Pinane Thromboxane A2
	15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.
T35680	2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide
	2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is an antimicrobial agent.1It is active against the Gram-negative bacteriaE. coli,P. aeruginosa, andS. marcescens(MICs = 64, 100, and 70 μg/ml, respectively), the Gram-positive bacteriaS. aureus,M. luteus, andB. cereus(MICs = 130, 100, and 50 μg/ml, respectively), and the fungiC. albicans,G. candidum,T. rubrum,F. oxysporum,A. flavus, andS. brevicaulis(MICs = 69-120 μg/ml). 2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is also a prec...
T38276	Benzomalvin C
	Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

化合物

Nodinitib-1

Cat.No: T6591

Synonym: ML130,CID-1088438

Target: TNF, NOD-like Receptor (NLR), NOD

15(R)-Pinane Thromboxane A2

Cat.No: T36208

Synonym: 15(R)-Pinane Thromboxane A2

Target:

2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide

Cat. No.	Product Name	Target	Signaling Pathways
T37751	Streptazolin
	Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.
T36489	Malformin A
	Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferati...