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Search Results for " mapt "

5

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T64256	Emapticap pegol
	Emapticap pegol 是一种促炎趋化因子 C-C 基序配体 2 (CCL2) 抑制剂。Emapticap pegol 也是一种 40 个核苷酸的寡核苷酸适体，在人 (NOX-E36) 和小鼠 (mNOX-E36) 中表现出不同的 Spiegelmers (L-RNA 适配子) 形式。
T34132	Primapterin L-Erythro-7-isobiopterin,7-Isobiopterin
	Primapterin, 7-Substituted pterins, is a new type of mammalian pteridines.
T81865	MAPTAM
	MAPTAM是一种能够螯合细胞内Ca2+的化合物。
T73992	IONIS-MAPTRx
	IONIS-MAPTRx (BIIB080) 是一个降低 Tau 的反义寡核苷酸 (ASO)。IONIS-MAPTRx 具有研究阿尔茨海默病的潜力。( MCE IONIS-MAPTRx 用于小鼠: TauASO-12序列 – 5′ GCTTTTACTGACCATGCGAG 3′ )
T80616	Posdinemab
	Posdinemab为一种针对微管相关蛋白tau (MAPT)的人源化IgG1κ抗体。

化合物

Emapticap pegol

Cat.No: T64256

Cat.No: T34132

Synonym: L-Erythro-7-isobiopterin,7-Isobiopterin

Cat.No: T81865

Cat.No: T73992

Cat.No: T80616

Cat. No.	Product Name	Target	Signaling Pathways
T11060	DMAPT Dimethylamino Parthenolide	NF-κB	NF-κB
	DMAPT (Dimethylamino Parthenolide) 是一种具有口服活性的NF-κB 抑制剂，是一种 Parthenolide (PTL) 的类似物，对原发性急性髓性白血病细胞的LD50值为1.7 μM。具有潜在的抗肿瘤和抗转移作用。

天然产物

Cat.No: T11060

Synonym: Dimethylamino Parthenolide

Target: NF-κB

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03425	Tau Protein, Human, Recombinant (His) PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-as...	Human	E. coli
	MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP...
TMPJ-00827	Tau-D Protein, Human, Recombinant (His) PHF-Tau,MAPTL,MAPT,Paired Helical Filament...	Human	E. coli
	Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective,...
TMPJ-00828	Tau-F Protein, Human, Recombinant Neurofibrillary tangle protein,Paired helical filament-tau,<...	Human	E. coli
	Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def...
TMPJ-01076	FKBP4 Protein, Human, Recombinant (His) FKBP4,HSP-binding immunophilin,immunophilin FKBP52,FK506-bin...	Human	E. coli
	FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
TMPH-02228	TRA2B Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
TMPH-01683	Tau Protein, Human, Recombinant (HEK293, His)	Human	HEK293 Cells
	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the ...
TMPH-02229	TRA2B Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. TRA2B Protein, Human, Recombinant (His & SUMO) is expr...
TMPH-02275	Lck Protein, Human, Recombinant (His)	Human	E. coli
	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His)	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

Tau Protein, Human, Recombinant (His)

Cat.No: TMPY-03425

Species: Human

Expression System: E. coli

Tau-D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00827

Species: Human

Expression System: E. coli

Tau-F Protein, Human, Recombinant

Cat.No: TMPJ-00828

Species: Human

Expression System: E. coli

FKBP4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01076

Species: Human

Expression System: E. coli

TRA2B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02228

Species: Human

Expression System: Baculovirus Insect Cells

Tau Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPH-01683

Species: Human

Expression System: HEK293 Cells

TRA2B Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02229

Species: Human

Expression System: E. coli

Lck Protein, Human, Recombinant (His)

Cat.No: TMPH-02275

Species: Human

Expression System: E. coli

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

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