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Search Results for " m-calpain "

Targets Recommended: Cysteine Protease Proteasome

3

抑制剂 & 化合物

1

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2493	PD 151746	Cysteine Protease; Proteasome	Proteases/Proteasome; Ubiquitination
	PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].
T3525	PD150606	Cysteine Protease	Proteases/Proteasome
	PD150606 是一种具有选择性的非肽 calpain 抑制剂，具有神经保护活性，抑制 μ-calpains 和 m-calpains ，抑制红藻氨酸诱导的 Ca2+ 内流，干扰兴奋性毒性依赖性运动神经元死亡。
T21949	Calpain Inhibitor XII
	(Rac)-Calpain Inhibitor XII是一种可逆的，选择性抑制钙蛋白酶I（calpain I; μ-calpain）的化合物，具有19 nM的Ki值。其对钙蛋白酶II（calpain II; m-calpain; Ki=120 nM）和组织蛋白酶B（cathepsin B; Ki=750 nM）显示出较低的抑制亲和力。(Rac)-Calpain Inhibitor XII用于研究钙蛋白酶在多种生理过程中的角色，如嗜中性粒细胞趋化性、神经元信号传导和心脏对损伤的响应。

化合物

Cat.No: T2493

Target: Cysteine Protease, Proteasome

Cat.No: T3525

Target: Cysteine Protease

Calpain Inhibitor XII

Cat.No: T21949

Cat. No.	Product Name	Target	Signaling Pathways
T36931	Penicillide
	Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells.

天然产物

Cat.No: T36931

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01031	CAPN2 Protein, Human, Recombinant (His) Calpain-2 catalytic subunit,Millimolar-calpain<...	Human	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. CAPN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82...

重组蛋白

CAPN2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01031

Species: Human

Expression System: E. coli

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