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Search Results for " ltbr "

Targets Recommended: Others NF-κB LTR

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11886	LTβR-IN-1	Others; NF-κB; LTR	Immunology/Inflammation; NF-κB; Others
	LTβR-IN-1是一种有作用的、具有选择性的淋巴素β受体(LTβR)抑制剂。LTβR-IN-1 对TNF12A 的的 p52 的核易位抑制作用具有选择性，对 TNF-α 受体介导的 p65 的核易位无明显作用，却抑制受 TWEAK 或 Anti-LTβR 刺激的 p52 核易位，IC50为10 μM。LTβR-IN-1通过配体非依赖性方式实现对 NF-kB 信号通路的调节作用。

化合物

LTβR-IN-1

Cat.No: T11886

Synonym:

Target: Others, NF-κB, LTR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00994	LTBR Protein, Mouse, Recombinant (hFc) Tnfcr,Lymphotoxin-beta receptor,Tumor necrosis factor recept...	Mouse	HEK293 Cells
	It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs...
TMPY-05039	LTBR Protein, Human, Recombinant (hFc) TNFR-RP,lymphotoxin β receptor (TNFR superfamily, member 3),...	Human	HEK293 Cells
	LTBR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.8 kDa and the accession number is P36941-1.
TMPJ-00274	LTBR Protein, Human, Recombinant (His) TNFCR,Tumor Necrosis Factor Receptor Superfamily Member 3,Ly...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 3, also known as Lymphotoxin-beta receptor,Tumor necrosis factor C receptor,Tumor necrosis factor receptor 2-related protein,Tumor necrosis factor receptor type III,LTBR,TNFCR, TNFR3 and TNFRSF3, is a member of the tumor necrosis factor (TNF) family of receptors. LTBR is a single-pass type I membrane protein and contains four TNFR-Cys repeats. It is expressed on the surface of most cell types, but not on T and B lymphocytes. LTBR and its ligand p...
TMPY-03252	LTBR Protein, Cynomolgus, Recombinant (hFc) lymphotoxin β receptor (TNFR superfamily, member 3),lymphoto...	Cynomolgus	HEK293 Cells
	LTBR Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.8 kDa and the accession number is F6V995.
TMPY-02771	LTBR Protein, Rat, Recombinant (His) lymphotoxin beta receptor (TNFR superfamily, member 3),lymph...	Rat	HEK293 Cells
	LTBR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23 kDa and the accession number is Q5U2S8.
TMPY-03583	LTBR Protein, Rat, Recombinant (hFc) lymphotoxin beta receptor (TNFR superfamily, member 3),lymph...	Rat	HEK293 Cells
	LTBR Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.5 kDa and the accession number is Q5U2S8.
TMPY-02153	TNF beta Protein, Human, Recombinant LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymphotoxin α	Human	E. coli
	Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS...
TMPH-01620	TNF beta Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
TMPH-02770	TNF beta Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. TNF beta Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.8 kDa and the accession number is P09225.
TMPH-02208	TRAF3 Protein, Human, Recombinant	Human	E. coli
	Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein liga...